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Efficacy of sulphadoxine-pyrimethamine + artesunate, sulphadoxine-pyrimethamine + amodiaquine, and sulphadoxine-pyrimethamine alone in uncomplicated falciparum malaria in Mali.
Maiga, Hamma; Djimde, Abdoulaye A; Beavogui, Abdoul H; Toure, Ousmane; Tekete, Mamadou; Sangare, Cheick Papa O; Dara, Antoine; Traore, Zoumana I; Traore, Oumar B; Dama, Souleymane; N'Dong, Christelle; Niangaly, Hamidou; Diallo, Nouhoum; Dembele, Demba; Sagara, Issaka; Doumbo, Ogobara K.
Afiliación
  • Maiga H; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. hmaiga@icermali.org.
  • Djimde AA; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. adjimde@icermali.org.
  • Beavogui AH; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. beavoguia_h@yahoo.com.
  • Toure O; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. obtoure@icermali.org.
  • Tekete M; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. mtekete@icermali.org.
  • Sangare CP; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. oumar@icermali.org.
  • Dara A; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. tonydara@icermali.org.
  • Traore ZI; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. zouisaac@gmail.com.
  • Traore OB; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. bila@icermali.org.
  • Dama S; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. dama@icermali.org.
  • N'Dong C; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. chris_ndong@hotmail.com.
  • Niangaly H; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. hniangaly@icermali.org.
  • Diallo N; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. nouhoumd@icermali.org.
  • Dembele D; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. ddembele@icermali.org.
  • Sagara I; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. isagara@icermali.org.
  • Doumbo OK; Molecular Epidemiology and Drug Resistance Unit, University of Sciences Techniques and Technology of Bamako, PO Box: 1805, Bamako, Mali. okd@icermali.org.
Malar J ; 14: 64, 2015 Feb 07.
Article en En | MEDLINE | ID: mdl-25889633
BACKGROUND: Plasmodium falciparum resistance to artemisinin has been reported in South-East Asia. Long half-life drugs are increasingly being used for malaria prevention. The potential spread of parasite resistance to these regimens is real and makes regular efficacy surveillance a priority. METHODS: From August to December 2004 and July to December 2005, a randomized open label trial of sulphadoxine-pyrimethamine (SP) + artesunate (AS) versus SP + amodiaquine (AQ), and SP alone, was conducted in two villages of Mali. PCR was used to distinguish new infections from recrudescent P. falciparum infections. Patients were followed for 28 days to assess treatment efficacy. RESULTS: Overall 912 children aged between six to 59 months, with uncomplicated P. falciparum malaria were recruited. Baseline characteristics were similar in the three treatment arms. Crude ACPRs were 94.9%; 98.6% and 93.5% for SP + AS; SP + AQ and SP alone arms respectively (SP + AS versus SP + AQ, p = 0.01; SP + AS versus SP, p = 0.5; SP + AQ versus SP, p = 0.001). After PCR adjustment, cACPRs were 99%; 100% and 97.2% for SP + AS; SP + AQ and SP alone arms, respectively (SP + AS versus SP + AQ, p = 0.25; SP + AS versus SP, p = 0.12; SP + AQ versus SP, p = 0.007). CONCLUSION: Sulphadoxine-pyrimethamine + amodiaquine therapy was as efficacious as sulphadoxine-pyrimethamine + artesunate, but more efficacious than sulphadoxine-pyrimethamine alone in the treatment of uncomplicated P. falciparum malaria in Mali.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimetamina / Sulfadoxina / Malaria Falciparum / Artemisininas / Amodiaquina / Antimaláricos Tipo de estudio: Clinical_trials Límite: Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Malar J Asunto de la revista: MEDICINA TROPICAL Año: 2015 Tipo del documento: Article País de afiliación: Mali Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimetamina / Sulfadoxina / Malaria Falciparum / Artemisininas / Amodiaquina / Antimaláricos Tipo de estudio: Clinical_trials Límite: Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Malar J Asunto de la revista: MEDICINA TROPICAL Año: 2015 Tipo del documento: Article País de afiliación: Mali Pais de publicación: Reino Unido