Mathematical modelling of tumour volume dynamics in response to stereotactic ablative radiotherapy for non-small cell lung cancer.
Phys Med Biol
; 60(9): 3695-713, 2015 May 07.
Article
en En
| MEDLINE
| ID: mdl-25884575
This paper reports a modelling study of tumour volume dynamics in response to stereotactic ablative radiotherapy (SABR). The main objective was to develop a model that is adequate to describe tumour volume change measured during SABR, and at the same time is not excessively complex as lacking support from clinical data. To this end, various modelling options were explored, and a rigorous statistical method, the Akaike information criterion, was used to help determine a trade-off between model accuracy and complexity. The models were calibrated to the data from 11 non-small cell lung cancer patients treated with SABR. The results showed that it is feasible to model the tumour volume dynamics during SABR, opening up the potential for using such models in a clinical environment in the future.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Algoritmos
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Planificación de la Radioterapia Asistida por Computador
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Radiocirugia
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Carcinoma de Pulmón de Células no Pequeñas
/
Carga Tumoral
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Phys Med Biol
Año:
2015
Tipo del documento:
Article
Pais de publicación:
Reino Unido