Your browser doesn't support javascript.
loading
Cognitive impact of anticholinergic medication in MS: Adding insult to injury?
Cruce, Roxana; Vosoughi, Reza; Freedman, Mark S.
Afiliación
  • Cruce R; The Ottawa Hospital Research Institute, Ottawa, Canada; Division of Neurology, MS Clinic, The Ottawa Hospital, Ottawa, Canada; University of Ottawa, The Ottawa Hospital-General Campus, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6.
  • Vosoughi R; The Ottawa Hospital Research Institute, Ottawa, Canada; Division of Neurology, MS Clinic, The Ottawa Hospital, Ottawa, Canada; University of Ottawa, The Ottawa Hospital-General Campus, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6.
  • Freedman MS; The Ottawa Hospital Research Institute, Ottawa, Canada; Division of Neurology, MS Clinic, The Ottawa Hospital, Ottawa, Canada; University of Ottawa, The Ottawa Hospital-General Campus, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6. Electronic address: mfreedman@toh.on.ca.
Mult Scler Relat Disord ; 1(4): 156-61, 2012 Oct.
Article en En | MEDLINE | ID: mdl-25877263
BACKGROUND: Cognitive impairment in Multiple Sclerosis (MS) is well recognized, being documented even in the earliest stages of the disease. Anticholinergic drugs (ACD) are frequently used to address bladdder symptoms in this population. ACD are known for their deleterious cognitive effects in older individuals; however their potential impact on cognition has received less attention in the context of MS. OBJECTIVE: To explore possible detrimental effects of bladder-directed ACD on cognitive functioning in MS. METHODS: 42 MS patients who had been on classical, bladder-directed ACD for ≥6 months were compared to 46 patients not receiving ACD, in terms of their scores on Symbol Digit Modality Test (SDMT) and Selective Reminding Test (SRT). Patients also completed questionnaires for fatigue (Modified Fatigue Impact Scale - MFIS) and depression (Beck Depression Inventory-Fast Screen - BDIFS). RESULTS: Patients using ACD showed significantly lower SDMT and SRT scores compared to those not using ACD (p<0.001; t-test). The association of lower cognitive test performance with ACD usage was robust, even when other variables (like age, gender, EDSS, etc.) were considered. CONCLUSION: Our results suggest that chronic use of classical ACD for bladder symptoms may have a negative impact on cognitive functioning in MS patients. These potential cognitive side effects need to be considered both in clinical practice and research settings.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mult Scler Relat Disord Año: 2012 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mult Scler Relat Disord Año: 2012 Tipo del documento: Article Pais de publicación: Países Bajos