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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Sidrauski, Carmela; Tsai, Jordan C; Kampmann, Martin; Hearn, Brian R; Vedantham, Punitha; Jaishankar, Priyadarshini; Sokabe, Masaaki; Mendez, Aaron S; Newton, Billy W; Tang, Edward L; Verschueren, Erik; Johnson, Jeffrey R; Krogan, Nevan J; Fraser, Christopher S; Weissman, Jonathan S; Renslo, Adam R; Walter, Peter.
Afiliación
  • Sidrauski C; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
  • Tsai JC; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
  • Kampmann M; Howard Hughes Medical Institution, University of California, San Francisco, San Francisco, United States.
  • Hearn BR; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.
  • Vedantham P; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.
  • Jaishankar P; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.
  • Sokabe M; Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, United States.
  • Mendez AS; Howard Hughes Medical Institution, University of California, San Francisco, San Francisco, United States.
  • Newton BW; QB3, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, United States.
  • Tang EL; QB3, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, United States.
  • Verschueren E; QB3, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, United States.
  • Johnson JR; QB3, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, United States.
  • Krogan NJ; QB3, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, United States.
  • Fraser CS; Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, United States.
  • Weissman JS; Howard Hughes Medical Institution, University of California, San Francisco, San Francisco, United States.
  • Renslo AR; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.
  • Walter P; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
Elife ; 4: e07314, 2015 Apr 15.
Article en En | MEDLINE | ID: mdl-25875391
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nootrópicos / Fármacos Neuroprotectores / Factor 2B Eucariótico de Iniciación / Ciclohexilaminas / Subunidades de Proteína / Acetamidas Tipo de estudio: Prognostic_studies Idioma: En Revista: Elife Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nootrópicos / Fármacos Neuroprotectores / Factor 2B Eucariótico de Iniciación / Ciclohexilaminas / Subunidades de Proteína / Acetamidas Tipo de estudio: Prognostic_studies Idioma: En Revista: Elife Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido