The CRISPR-Cas immune system: biology, mechanisms and applications.
Biochimie
; 117: 119-28, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-25868999
Viruses are a common threat to cellular life, not the least to bacteria and archaea who constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus infection has evolved. A recent discovery is the adaptive immune system in prokaryotes, a type of system previously thought to be present only in vertebrates. The system, called CRISPR-Cas, provide sequence-specific adaptive immunity and fundamentally affect our understanding of virus-host interaction. CRISPR-based immunity acts by integrating short virus sequences in the cell's CRISPR locus, allowing the cell to remember, recognize and clear infections. There has been rapid advancement in our understanding of this immune system and its applications, but there are many aspects that await elucidation making the field an exciting area of research. This review provides an overview of the field and highlights unresolved issues.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus
/
Virosis
/
Interacciones Huésped-Patógeno
/
Sistemas CRISPR-Cas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochimie
Año:
2015
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Francia