Role of pleiotropy during adaptation of TEM-1 ß-lactamase to two novel antibiotics.

Schenk, Martijn F; Witte, Sariette; Salverda, Merijn L M; Koopmanschap, Bertha; Krug, Joachim; de Visser, J Arjan G M

Schenk, Martijn F; Witte, Sariette; Salverda, Merijn L M; Koopmanschap, Bertha; Krug, Joachim; de Visser, J Arjan G M.

Afiliación

Schenk MF; Institute of Genetics, University of Cologne Köln, Germany ; Laboratory of Genetics, Wageningen University Wageningen, The Netherlands.
Witte S; Laboratory of Genetics, Wageningen University Wageningen, The Netherlands.
Salverda ML; Laboratory of Genetics, Wageningen University Wageningen, The Netherlands.
Koopmanschap B; Laboratory of Genetics, Wageningen University Wageningen, The Netherlands.
Krug J; Institute for Theoretical Physics, University of Cologne Köln, Germany ; Systems Biology of Ageing Cologne (Sybacol), University of Cologne Köln, Germany.
de Visser JA; Laboratory of Genetics, Wageningen University Wageningen, The Netherlands.

Evol Appl ; 8(3): 248-60, 2015 Mar.

Article en En | MEDLINE | ID: mdl-25861383

Palabras clave

TEM-1 ß-lactamase; antibiotic resistance; epistasis; pleiotropy; protein evolution; trade-off

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Evol Appl Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido

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