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Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding.
Xue, Yali; Prado-Martinez, Javier; Sudmant, Peter H; Narasimhan, Vagheesh; Ayub, Qasim; Szpak, Michal; Frandsen, Peter; Chen, Yuan; Yngvadottir, Bryndis; Cooper, David N; de Manuel, Marc; Hernandez-Rodriguez, Jessica; Lobon, Irene; Siegismund, Hans R; Pagani, Luca; Quail, Michael A; Hvilsom, Christina; Mudakikwa, Antoine; Eichler, Evan E; Cranfield, Michael R; Marques-Bonet, Tomas; Tyler-Smith, Chris; Scally, Aylwyn.
Afiliación
  • Xue Y; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Prado-Martinez J; Institut de Biologia Evolutiva (CSIC/UPF), Parque de Investigación Biomédica de Barcelona (PRBB), Barcelona, Catalonia 08003, Spain.
  • Sudmant PH; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
  • Narasimhan V; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Ayub Q; Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK.
  • Szpak M; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Frandsen P; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Chen Y; Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
  • Yngvadottir B; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Cooper DN; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • de Manuel M; Institute of Medical Genetics, Cardiff University, Cardiff CF14 4XN, UK.
  • Hernandez-Rodriguez J; Institut de Biologia Evolutiva (CSIC/UPF), Parque de Investigación Biomédica de Barcelona (PRBB), Barcelona, Catalonia 08003, Spain.
  • Lobon I; Institut de Biologia Evolutiva (CSIC/UPF), Parque de Investigación Biomédica de Barcelona (PRBB), Barcelona, Catalonia 08003, Spain.
  • Siegismund HR; Institut de Biologia Evolutiva (CSIC/UPF), Parque de Investigación Biomédica de Barcelona (PRBB), Barcelona, Catalonia 08003, Spain.
  • Pagani L; Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
  • Quail MA; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Hvilsom C; Department of Biological, Geological and Environmental Sciences, University of Bologna, 40134 Bologna, Italy.
  • Mudakikwa A; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Eichler EE; Research and Conservation, Copenhagen Zoo, DK-2000 Frederiksberg, Denmark.
  • Cranfield MR; Rwanda Development Board, KG 9 Avenue, Kigali, Rwanda.
  • Marques-Bonet T; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
  • Tyler-Smith C; Howard Hughes Medical Institute, Seattle, WA 91895, USA.
  • Scally A; Gorilla Doctors, Karen C. Drayer Wildlife Health Center, University of California, Davis, CA 95616, USA.
Science ; 348(6231): 242-245, 2015 Apr 10.
Article en En | MEDLINE | ID: mdl-25859046
Mountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and evolutionary past. We sequenced whole genomes from multiple wild individuals and compared the genomes of all four Gorilla subspecies. We found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation. A further recent decline in the mountain gorilla population has led to extensive inbreeding, such that individuals are typically homozygous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from the population. We discuss the causes of their decline and the consequences for their future survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Genoma / Gorilla gorilla / Endogamia Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Science Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Genoma / Gorilla gorilla / Endogamia Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Science Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos