Antibiotic-free selection in biotherapeutics: now and forever.
Pathogens
; 4(2): 157-81, 2015 Apr 03.
Article
en En
| MEDLINE
| ID: mdl-25854922
The continuously improving sophistication of molecular engineering techniques gives access to novel classes of bio-therapeutics and new challenges for their production in full respect of the strengthening regulations. Among these biologic agents are DNA based vaccines or gene therapy products and to a lesser extent genetically engineered live vaccines or delivery vehicles. The use of antibiotic-based selection, frequently associated with genetic manipulation of microorganism is currently undergoing a profound metamorphosis with the implementation and diversification of alternative selection means. This short review will present examples of alternatives to antibiotic selection and their context of application to highlight their ineluctable invasion of the bio-therapeutic world.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Pathogens
Año:
2015
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Suiza