Targeting ion channels for cancer therapy by repurposing the approved drugs.
Biochim Biophys Acta
; 1848(10 Pt B): 2747-55, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-25843679
Ion channels have been shown to be involved in oncogenesis and efforts are being poured in to target the ion channels. There are many clinically approved drugs with ion channels as "off" targets. The question is, can these drugs be repurposed to inhibit ion channels for cancer treatment? Repurposing of drugs will not only save investors' money but also result in safer drugs for cancer patients. Advanced bioinformatics techniques and availability of a plethora of open access data on FDA approved drugs for various indications and omics data of large number of cancer types give a ray of hope to look for possibility of repurposing those drugs for cancer treatment. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bloqueadores de los Canales de Calcio
/
Canales de Potasio
/
Regulación Neoplásica de la Expresión Génica
/
Canales de Calcio Tipo N
/
Bloqueadores de los Canales de Potasio
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Países Bajos