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Functionalization of strongly interacting magnetic nanocubes with (thermo)responsive coating and their application in hyperthermia and heat-triggered drug delivery.
Kakwere, Hamilton; Leal, Manuel Pernia; Materia, Maria Elena; Curcio, Alberto; Guardia, Pablo; Niculaes, Dina; Marotta, Roberto; Falqui, Andrea; Pellegrino, Teresa.
Afiliación
  • Kakwere H; †Istituto Italiano di Tecnologia, via Morego 30, 16143, Genova, Italy.
  • Leal MP; †Istituto Italiano di Tecnologia, via Morego 30, 16143, Genova, Italy.
  • Materia ME; †Istituto Italiano di Tecnologia, via Morego 30, 16143, Genova, Italy.
  • Curcio A; †Istituto Italiano di Tecnologia, via Morego 30, 16143, Genova, Italy.
  • Guardia P; †Istituto Italiano di Tecnologia, via Morego 30, 16143, Genova, Italy.
  • Niculaes D; †Istituto Italiano di Tecnologia, via Morego 30, 16143, Genova, Italy.
  • Marotta R; †Istituto Italiano di Tecnologia, via Morego 30, 16143, Genova, Italy.
  • Falqui A; †Istituto Italiano di Tecnologia, via Morego 30, 16143, Genova, Italy.
  • Pellegrino T; ‡King Abdullah University of Science and Technology (KAUST), BESE division, Thuwal, Kingdom of Saudi Arabia.
ACS Appl Mater Interfaces ; 7(19): 10132-45, 2015 May 20.
Article en En | MEDLINE | ID: mdl-25840122
Herein, we prepare nanohybrids by incorporating iron oxide nanocubes (cubic-IONPs) within a thermoresponsive polymer shell that can act as drug carriers for doxorubicin(doxo). The cubic-shaped nanoparticles employed are at the interface between superparamagnetic and ferromagnetic behavior and have an exceptionally high specific absorption rate (SAR), but their functionalization is extremely challenging compared to bare superparamagnetic iron oxide nanoparticles as they strongly interact with each other. By conducting the polymer grafting reaction using reversible addition-fragmentation chain transfer (RAFT) polymerization in a viscous solvent medium, we have here developed a facile approach to decorate the nanocubes with stimuli-responsive polymers. When the thermoresponsive shell is composed of poly(N-isopropylacrylamide-co-polyethylene glycolmethyl ether acrylate), nanohybrids have a phase transition temperature, the lower critical solution temperature (LCST), above 37 °C in physiological conditions. Doxo loaded nanohybrids exhibited a negligible drug release below 37 °C but showed a consistent release of their cargo on demand by exploiting the capability of the nanocubes to generate heat under an alternating magnetic field (AMF). Moreover, the drug free nanocarrier does not exhibit cytotoxicity even when administered at high concentration of nanocubes (1g/L of iron) and internalized at high extent (260 pg of iron per cell). We have also implemented the synthesis protocol to decorate the surface of nanocubes with poly(vinylpyridine) polymer and thus prepare pH-responsive shell coated nanocubes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Preparaciones de Acción Retardada / Nanopartículas de Magnetita / Hipertermia Inducida / Neoplasias Experimentales Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2015 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Preparaciones de Acción Retardada / Nanopartículas de Magnetita / Hipertermia Inducida / Neoplasias Experimentales Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2015 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos