Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia.

Lepeta, Katarzyna; Kaczmarek, Leszek

Lepeta, Katarzyna; Kaczmarek, Leszek.

Afiliación

Lepeta K; Department of Molecular and Cellular Neurobiology, Nencki Institute, Warsaw, Poland.
Kaczmarek L; Department of Molecular and Cellular Neurobiology, Nencki Institute, Warsaw, Poland l.kaczmarek@nencki.gov.pl.

Schizophr Bull ; 41(5): 1003-9, 2015 Sep.

Article en En | MEDLINE | ID: mdl-25837304

RESUMEN

Recent findings implicate alterations in glutamate signaling, leading to aberrant synaptic plasticity, in schizophrenia. Matrix metalloproteinase-9 (MMP-9) has been shown to regulate glutamate receptors, be regulated by glutamate at excitatory synapses, and modulate physiological and morphological synaptic plasticity. By means of functional gene polymorphism, gene responsiveness to antipsychotics and blood plasma levels MMP-9 has recently been implicated in schizophrenia. This commentary critically reviews these findings based on the hypothesis that MMP-9 contributes to pathological synaptic plasticity in schizophrenia.

Asunto(s)

Metaloproteinasa 9 de la Matriz/metabolismo; Plasticidad Neuronal/fisiología; Receptores de Glutamato/metabolismo; Esquizofrenia/metabolismo; Humanos; Metaloproteinasa 9 de la Matriz/genética; Esquizofrenia/genética

Palabras clave

extracellular matrix; glutamate; synaptic plasticity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Receptores de Glutamato / Metaloproteinasa 9 de la Matriz / Plasticidad Neuronal Límite: Humans Idioma: En Revista: Schizophr Bull Año: 2015 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos

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