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Association between Smoking and Uveitis: Results from the Pacific Ocular Inflammation Study.
Yuen, Brenton G; Tham, Vivien M; Browne, Erica N; Weinrib, Rachel; Borkar, Durga S; Parker, John V; Uchida, Aileen; Vinoya, Aleli C; Acharya, Nisha R.
Afiliación
  • Yuen BG; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California; University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii.
  • Tham VM; University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii; Department of Ophthalmology, Kaiser Permanente Hawaii, Honolulu, Hawaii; Pacific Vision Institute of Hawaii, Honolulu, Hawaii.
  • Browne EN; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California.
  • Weinrib R; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California.
  • Borkar DS; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California.
  • Parker JV; Center for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii.
  • Uchida A; Center for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii.
  • Vinoya AC; Center for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii.
  • Acharya NR; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California; Department of Ophthalmology, University of California, San Francisco, San Francisco, Californ
Ophthalmology ; 122(6): 1257-61, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25835263
PURPOSE: To assess whether cigarette smoking is associated with the development of uveitis in a population-based setting. DESIGN: Retrospective, population-based, case-control study. PARTICIPANTS: Patients aged ≥ 18 years who were seen at a Kaiser Permanente Hawaii clinic between January 1, 2006, and December 31, 2007. Analysis included 100 confirmed incident uveitis cases, 522 randomly selected controls from the general Kaiser Hawaii population, and 528 randomly selected controls from the Kaiser Hawaii ophthalmology clinic. METHODS: International Classification of Diseases, 9th revision (ICD-9), diagnosis codes were used to identify possible uveitis cases. A uveitis fellowship-trained ophthalmologist then conducted individual chart review to confirm case status. Multivariate logistic regression models were used to evaluate the association between smoking and uveitis, adjusting for age, sex, race, and socioeconomic status. MAIN OUTCOME MEASURES: Development of uveitis. RESULTS: Current smokers had a 1.63 (95% confidence interval [CI], 0.88-3.00; P = 0.12) and 2.33 (95% CI, 1.22-4.45; P = 0.01) times greater odds of developing uveitis compared with those who never smoked using the general and ophthalmology control groups, respectively. The association was even stronger with noninfectious uveitis, which yielded odds ratios of 2.10 (95% CI, 1.10-3.99; P = 0.02) and 2.96 (95% CI, 1.52-5.77; P = 0.001) using the general and ophthalmology control groups, respectively. CONCLUSIONS: Cigarette smoking is significantly associated with new-onset uveitis within a population-based setting. The association was stronger for noninfectious uveitis. Given the well-established risks of smoking with regard to other inflammatory disorders, these results reaffirm the importance of encouraging patients to avoid or cease smoking.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uveítis / Fumar Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Ophthalmology Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uveítis / Fumar Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Ophthalmology Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos