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Association of cholesterol with risk of pancreatic cancer: a meta-analysis.
Wang, Jia; Wang, Wei-Jing; Zhai, Long; Zhang, Dong-Feng.
Afiliación
  • Wang J; Jia Wang, Wei-Jing Wang, Long Zhai, Dong-Feng Zhang, Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao 266021, Shandong Province, China.
  • Wang WJ; Jia Wang, Wei-Jing Wang, Long Zhai, Dong-Feng Zhang, Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao 266021, Shandong Province, China.
  • Zhai L; Jia Wang, Wei-Jing Wang, Long Zhai, Dong-Feng Zhang, Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao 266021, Shandong Province, China.
  • Zhang DF; Jia Wang, Wei-Jing Wang, Long Zhai, Dong-Feng Zhang, Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao 266021, Shandong Province, China.
World J Gastroenterol ; 21(12): 3711-9, 2015 Mar 28.
Article en En | MEDLINE | ID: mdl-25834340
AIM: To evaluate the effect of dietary cholesterol and serum total cholesterol (TC) on the risk of pancreatic cancer. METHODS: A literature search was performed up to June 2014 in PubMed, EMBASE, China National Knowledge Infrastructure and China Biology Medical literature database for relevant articles published in English or Chinese. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model. RESULTS: We included 14 published articles with 439355 participants for dietary cholesterol, and 6 published articles with 1805697 participants for serum TC. For the highest vs lowest category of dietary cholesterol, the pooled RR (95%CI) of pancreatic cancer was 1.308 (1.097-1.559). After excluding two studies (RR > 3.0), the pooled RR (95%CI) was 1.204 (1.050-1.380). In subgroup analysis stratified by study design, the pooled RRs (95%CIs) were 1.523 (1.226-1.893) for case-control studies and 1.023 (0.871-1.200) for cohort studies. The association of dietary cholesterol with the risk of pancreatic cancer was significant for studies conducted in North America [1.275 (1.058-1.537)] and others [2.495 (1.565-3.977)], but not in Europe [1.149 (0.863-1.531)]. No significant association [1.003 (0.859-1.171)] was found between the risk of pancreatic cancer and serum TC. CONCLUSION: Dietary cholesterol may be associated with an increased risk of pancreatic cancer in worldwide populations, except for Europeans. The results need to be confirmed further.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Colesterol en la Dieta / Hipercolesterolemia Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Colesterol en la Dieta / Hipercolesterolemia Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos