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Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis.
Diwakar, Amit; Adam, Ryan J; Michalski, Andrew S; Tamegnon, Monelle M; Fischer, Anthony J; Launspach, Jan L; Horan, Rebecca A; Kao, Simon C; Chaloner, Kathryn; Meyerholz, David K; Stoltz, David A.
Afiliación
  • Diwakar A; Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
  • Adam RJ; Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
  • Michalski AS; Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, Iowa.
  • Tamegnon MM; Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
  • Fischer AJ; Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, U.S.A.
  • Launspach JL; Department of Pediatrics, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
  • Horan RA; Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
  • Kao SC; Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
  • Chaloner K; Department of Radiology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
  • Meyerholz DK; Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, U.S.A.
  • Stoltz DA; Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
Laryngoscope ; 125(10): 2398-404, 2015 Oct.
Article en En | MEDLINE | ID: mdl-25827636
OBJECTIVES/HYPOTHESIS: Tracheal cartilage ring structural abnormalities have been reported in cystic fibrosis (CF) mice and pigs. Whether similar findings are present in humans with CF is unknown. We hypothesized that tracheal cartilage ring shape and size would be different in people with CF. STUDY DESIGN: Tracheal cartilage ring size and shape were measured in adults with (n = 21) and without CF (n = 18). METHODS: Ultrasonography was used in human subjects to noninvasively assess tracheal cartilage ring structure in both the sagittal and the transverse planes. Tracheal cartilage ring thickness was also determined from histological sections obtained from newborn non-CF and CF pigs. These values were compared with human data. RESULTS: Human CF tracheas had a greater width and were less circular in shape compared to non-CF subjects. CF tracheal cartilage rings had a greater midline cross-sectional area and were thicker compared to non-CF rings. Maximal tracheal cartilage ring thickness was also greater in both newborn CF pigs and human adults with CF, compared to non-CF controls. CONCLUSIONS: Our findings demonstrate that structural differences exist in tracheal cartilage rings in adults with CF. Comparison with newborn CF pig data suggests that some of these changes may be congenital in nature. LEVEL OF EVIDENCE: 3b
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tráquea / Cartílago / Fibrosis Quística Límite: Adolescent / Adult / Animals / Female / Humans / Male Idioma: En Revista: Laryngoscope Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tráquea / Cartílago / Fibrosis Quística Límite: Adolescent / Adult / Animals / Female / Humans / Male Idioma: En Revista: Laryngoscope Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos