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DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status.
Barbosa, Adriana Sierra Assencio Almeida; de Oliveira, Larissa Ragozo Cardoso; Tavares, Francilene Capel; de Lima, Carlos Roberto Gonçalves; Diório, Suzana Madeira; Calvi, Sueli Aparecida; Vilani-Moreno, Fátima Regina; Pereira, Paulo Câmara Marques.
Afiliación
  • Barbosa AS; Biology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil ; Equipe Técnica de Biologia, Instituto Lauro de Souza Lima, Rod. Comte. João Ribeiro de Barros, km 225/226, CEP 17.034-971 Bauru, SP Brazil.
  • de Oliveira LR; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
  • Tavares FC; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
  • de Lima CR; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
  • Diório SM; Microbiology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil.
  • Calvi SA; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
  • Vilani-Moreno FR; Biology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil.
  • Pereira PC; Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
J Venom Anim Toxins Incl Trop Dis ; 21: 10, 2015.
Article en En | MEDLINE | ID: mdl-25821459
BACKGROUND: Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet. METHODS: DNA damage was assessed in the peripheral blood by the comet assay (tail intensity). RESULTS: The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet. CONCLUSION: These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Venom Anim Toxins Incl Trop Dis Año: 2015 Tipo del documento: Article Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Venom Anim Toxins Incl Trop Dis Año: 2015 Tipo del documento: Article Pais de publicación: Brasil