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Superoxide Dismutase and Catalase Genotypes in Pediatric Migraine Patients.
Saygi, Semra; Erol, Ilknur; Alehan, Füsun; Yalçin, Yaprak Yilmaz; Kubat, Gözde; Ataç, Fatma Belgin.
Afiliación
  • Saygi S; Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey semra_saygi@yahoo.com.
  • Erol I; Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey.
  • Alehan F; Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey.
  • Yalçin YY; Department of Medical Biology, Baskent University School of Medicine, Ankara, Turkey.
  • Kubat G; Kazan Vocational School Business Administration Program, Baskent University, Ankara, Turkey.
  • Ataç FB; Department of Medical Biology, Baskent University School of Medicine, Ankara, Turkey.
J Child Neurol ; 30(12): 1586-90, 2015 Oct.
Article en En | MEDLINE | ID: mdl-25818327
This study compared superoxide dismutase (SOD) and catalase (CAT) alleles in 97 consecutive children and adolescents with migraine to 96 healthy children and adolescents. Isolated genomic DNA was used as a template for SOD1 (35 A/C), SOD2 16 C/T, and CAT2 [(-262 C/T) and (-21 A/T)] allele genotyping. The SOD2 16 C/T genotype and C allele frequency differed significantly between controls and migraine (P = .047; P = .038). CAT -21 AA genotype and A allele frequency were significantly higher in both migraine with aura patients (P = .013; P = .004) and migraine without aura patients (P = .003; P = .001) compared to controls. To our knowledge, this is the first demonstration of differences in SOD and CAT genotypes between pediatric migraine patients and age-matched controls. Further studies on the functional implications of these genetic variants on neural antioxidant capacity and the use of antioxidant modulators for migraine treatment are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Superóxido Dismutasa / Catalasa / Migraña con Aura / Migraña sin Aura Límite: Adolescent / Female / Humans / Male Idioma: En Revista: J Child Neurol Asunto de la revista: NEUROLOGIA / PEDIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Superóxido Dismutasa / Catalasa / Migraña con Aura / Migraña sin Aura Límite: Adolescent / Female / Humans / Male Idioma: En Revista: J Child Neurol Asunto de la revista: NEUROLOGIA / PEDIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos