Dimeric c-di-GMP is required for post-translational regulation of alginate production in Pseudomonas aeruginosa.

Whitney, John C; Whitfield, Gregory B; Marmont, Lindsey S; Yip, Patrick; Neculai, A Mirela; Lobsanov, Yuri D; Robinson, Howard; Ohman, Dennis E; Howell, P Lynne

Whitney, John C; Whitfield, Gregory B; Marmont, Lindsey S; Yip, Patrick; Neculai, A Mirela; Lobsanov, Yuri D; Robinson, Howard; Ohman, Dennis E; Howell, P Lynne.

Afiliación

Whitney JC; From the Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada, the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Whitfield GB; From the Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada, the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Marmont LS; From the Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada, the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Yip P; From the Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Neculai AM; From the Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Lobsanov YD; From the Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Robinson H; the Photon Sciences Division, Brookhaven National Laboratory, Upton, New York 11973-5000, and.
Ohman DE; the Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center and McGuire Veterans Affairs Medical Center, Richmond, Virginia 23298-0678.
Howell PL; From the Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada, the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, howell@sickkids.ca.

J Biol Chem ; 290(20): 12451-62, 2015 May 15.

Article en En | MEDLINE | ID: mdl-25817996

Asunto(s)

Alginatos/química; GMP Cíclico/análogos & derivados; Multimerización de Proteína; Pseudomonas aeruginosa/química; Factores de Virulencia/química; Proteínas Bacterianas; Sitios de Unión; Cristalografía por Rayos X; GMP Cíclico/química; GMP Cíclico/genética; GMP Cíclico/metabolismo; Ácido Glucurónico/química; Ácido Glucurónico/genética; Ácido Glucurónico/metabolismo; Ácidos Hexurónicos/química; Humanos; Proteínas de la Membrana; Mutación; Estructura Cuaternaria de Proteína; Pseudomonas aeruginosa/genética; Pseudomonas aeruginosa/metabolismo; Pseudomonas aeruginosa/patogenicidad; Factores de Virulencia/genética; Factores de Virulencia/metabolismo

Palabras clave

PilZ; Pseudomonas aeruginosa (P. aeruginosa); alginate; biofilm; crystal structure; cyclic di-GMP (c-di-GMP); exopolysaccharide; isothermal titration calorimetry (ITC)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / GMP Cíclico / Factores de Virulencia / Alginatos / Multimerización de Proteína Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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