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A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
Schappacher-Tilp, Gudrun; Leonard, Timothy; Desch, Gertrud; Herzog, Walter.
Afiliación
  • Schappacher-Tilp G; Department of Mathematics and Scientific Computing, University of Graz, 8010 Graz, Austria.
  • Leonard T; Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada.
  • Desch G; Department of Mathematics and Scientific Computing, University of Graz, 8010 Graz, Austria.
  • Herzog W; Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada.
PLoS One ; 10(3): e0117634, 2015.
Article en En | MEDLINE | ID: mdl-25816319
We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citoesqueleto de Actina / Músculo Esquelético / Modelos Biológicos / Contracción Muscular Tipo de estudio: Prognostic_studies Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citoesqueleto de Actina / Músculo Esquelético / Modelos Biológicos / Contracción Muscular Tipo de estudio: Prognostic_studies Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos