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Evolution of action potential alternans in rabbit heart during acute regional ischemia.
Martisiene, Irma; Jurevicius, Jonas; Vosyliute, Ruta; Navalinskas, Antanas; Treinys, Rimantas; Macianskiene, Regina; Benetis, Rimantas; Matiukas, Arvydas; Pertsov, Arkady M.
Afiliación
  • Martisiene I; Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.
  • Jurevicius J; Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.
  • Vosyliute R; Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.
  • Navalinskas A; Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.
  • Treinys R; Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.
  • Macianskiene R; Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.
  • Benetis R; Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.
  • Matiukas A; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210-2375, USA.
  • Pertsov AM; Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania ; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210-2375, USA.
Biomed Res Int ; 2015: 951704, 2015.
Article en En | MEDLINE | ID: mdl-25815342
This study investigates the development of the spatiotemporal pattern of action potential alternans during acute regional ischemia. Experiments were carried out in isolated Langendorff-perfused rabbit heart using a combination of optical mapping and microelectrode recordings. The alternans pattern significantly changed over time and had a biphasic character reaching maximum at 6-9 min after occlusion. Phase I (3-11 minutes of ischemia) is characterized by rapid increase in the alternans magnitude and expansion of the alternans territory. Phase I is followed by gradual decline of alternans (Phase II) in both magnitude and territory. During both phases we observed significant beat-to-beat variations of the optical action potential amplitude (OAPA) alternans. Simultaneous microelectrode recordings from subepicardial and subendocardial layers showed that OAPA alternans coincided with intramural 2 : 1 conduction blocks. Our findings are consistent with the modeling studies predicting that during acute regional ischemia alternans can be driven by 2 : 1 conduction blocks in the ischemic region.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciales de Acción / Isquemia Miocárdica / Glucanos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2015 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciales de Acción / Isquemia Miocárdica / Glucanos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2015 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Estados Unidos