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Plasma nitrate/nitrite removal by peritoneal dialysis might predispose infants with low blood pressure to cerebral ischaemia.
Carlström, Mattias; Wide, Katarina; Lundvall, Mikael; Cananau, Carmen; Svensson, Anders; Lundberg, Jon O; Bárány, Peter; Krmar, Rafael T.
Afiliación
  • Carlström M; Department of Physiology and Pharmacology , Karolinska Institute , Stockholm , Sweden.
  • Wide K; Karolinska Institute, Department for Clinical Science, Intervention and Technology, Division of Pediatrics , Karolinska University Hospital , Huddinge, Stockholm , Sweden.
  • Lundvall M; Karolinska Institute, Department for Clinical Science, Intervention and Technology, Division of Pediatrics , Karolinska University Hospital , Huddinge, Stockholm , Sweden.
  • Cananau C; Department of Radiology , Karolinska University Hospital , Huddinge, Stockholm , Sweden.
  • Svensson A; Department of Radiology , Karolinska University Hospital , Huddinge, Stockholm , Sweden.
  • Lundberg JO; Department of Physiology and Pharmacology , Karolinska Institute , Stockholm , Sweden.
  • Bárány P; Department of Renal Medicine , Karolinska University Hospital , Huddinge, Stockholm , Sweden.
  • Krmar RT; Karolinska Institute, Department for Clinical Science, Intervention and Technology, Division of Pediatrics , Karolinska University Hospital , Huddinge, Stockholm , Sweden.
Clin Kidney J ; 8(2): 215-8, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25815180
The underlying pathogenic mechanisms of neurological complications in infants undergoing peritoneal dialysis (PD) are poorly understood. We report on four male infants treated with PD who developed symptomatic cerebral ischaemia. Blood pressure (BP) levels were low both before the event and at presentation. In two patients, we observed that the removal of nitrate and nitrite by PD could have impaired the nitrate/nitrite--nitrite oxide (NO) pathway, a system that generates NO independently of NO synthase. Our observation suggests that low BP and reduced NO bioavailability puts infants treated with PD at risk for impaired cerebral blood flow and consequently for brain ischaemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Kidney J Año: 2015 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Kidney J Año: 2015 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido