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Hospital environment fungal contamination and aspergillosis risk in acute leukaemia patients in Sousse (Tunisia).
Gheith, Soukeina; Ranque, Stéphane; Bannour, Wadiaa; Ben Youssef, Yosra; Khelif, Abderrahim; Ben Said, Moncef; Njah, Mansour; Saghrouni, Fatma.
Afiliación
  • Gheith S; Service d'Hygiène Hospitalière, CHU Farhat Hached Sousse, Sousse, Tunisie.
  • Ranque S; Unité de recherche UR 12SP31, Ministère de la Santé Publique, Tunis, Tunisie.
  • Bannour W; Laboratoire de Parasitologie -Mycologie, CHU Farhat Hached, Sousse, Tunisie.
  • Ben Youssef Y; Laboratoire de Parasitologie -Mycologie, CHU Timone-Adultes, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Khelif A; Aix-Marseille Université, IP-TPT UMR MD3, Marseille, France.
  • Ben Said M; Service d'Hygiène Hospitalière, CHU Farhat Hached Sousse, Sousse, Tunisie.
  • Njah M; Service d'Hématologie clinique, CHU Farhat Hached, Sousse, Tunisie.
  • Saghrouni F; Service d'Hématologie clinique, CHU Farhat Hached, Sousse, Tunisie.
Mycoses ; 58(6): 337-42, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25809008
Hospital environment is considered the main source of invasive aspergillosis (IA) in leukemic patients. This study aimed to describe Aspergillus colonisation in leukemic patients and their hospital environment and to test whether Aspergillus environmental contamination was associated with IA. For a 2-year period including 14-month renovation work, 91 acute leukaemia inpatients at the hematology department of University hospital in Sousse (Tunisia) were prospectively included. The incidence of probable IA (EORTC/MSG criteria) was 9.9%. Fifty-six Aspergillus were isolated from 53 (6.5%) of 811 sputa collected from 35 (38.5%) patients. Aspergillus spp. were isolated in 59.7% of 494 air samples and in 52.8% of 1579 surface samples taken in the patients' room. Aspergillus section Nigri (72.7%) was the most frequent. Aspergillus contamination peaked in autumn and winter on surface and in summer and autumn in air samples and was higher (P = 0.03) during the renovation work period. Multivariate analysis showed that for each Aspergillus section Nigri CFU airborne contamination IA risk increased by 1.05 (P = 0.04). In Tunisia, Aspergillus section Nigri and Flavi, but not Fumigati, are chiefly involved in IA. Our findings support swift implementation of airborne fungal contamination control measures in areas where immunocompromised patient are hospitalised.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergilosis / Aspergillus / Leucemia / Microbiología del Aire Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Mycoses Asunto de la revista: MICROBIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergilosis / Aspergillus / Leucemia / Microbiología del Aire Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Mycoses Asunto de la revista: MICROBIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Alemania