Your browser doesn't support javascript.
loading
DNA copy number profiling reveals different patterns of chromosomal instability within colorectal cancer according to the age of onset.
Arriba, María; García, Juan L; Inglada-Pérez, Lucía; Rueda, Daniel; Osorio, Irene; Rodríguez, Yolanda; Álvaro, Edurne; Sánchez, Ricard; Fernández, Tamara; Pérez, Jessica; Hernández, Jesús M; Benítez, Javier; González-Sarmiento, Rogelio; Urioste, Miguel; Perea, José.
Afiliación
  • Arriba M; Centre for Biomedical Research of 12 de Octubre University Hospital, Madrid, Spain.
  • García JL; Biomedical Research Institute of Salamanca (IBSAL), University Hospital of Salamanca-USAL-CSIC, Salamanca, Spain.
  • Inglada-Pérez L; Institute of Molecular and Cellular Biology of Cancer (IBMCC), University of Salamanca-CSIC, Salamanca, Spain.
  • Rueda D; Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Osorio I; Center for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Madrid, Spain.
  • Rodríguez Y; Molecular Biology Laboratory, 12 de Octubre University Hospital, Madrid, Spain.
  • Álvaro E; Department of Surgery, 12 de Octubre University Hospital, Madrid, Spain.
  • Sánchez R; Department of Pathology, 12 de Octubre University Hospital, Madrid, Spain.
  • Fernández T; Department of Surgery, Infanta Leonor University Hospital, Madrid, Spain.
  • Pérez J; Centre for Biomedical Research of 12 de Octubre University Hospital, Madrid, Spain.
  • Hernández JM; Department of Surgery, 12 de Octubre University Hospital, Madrid, Spain.
  • Benítez J; Biomedical Research Institute of Salamanca (IBSAL), University Hospital of Salamanca-USAL-CSIC, Salamanca, Spain.
  • González-Sarmiento R; Institute of Molecular and Cellular Biology of Cancer (IBMCC), University of Salamanca-CSIC, Salamanca, Spain.
  • Urioste M; Biomedical Research Institute of Salamanca (IBSAL), University Hospital of Salamanca-USAL-CSIC, Salamanca, Spain.
  • Perea J; Center for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Madrid, Spain.
Mol Carcinog ; 55(5): 705-16, 2016 May.
Article en En | MEDLINE | ID: mdl-25808986
Chromosomal instability resulting in copy number alterations is a hallmark of colorectal cancer (CRC). However, few studies have attempted to characterize the chromosomal changes occurring in early-onset CRC in order to compare them with those taking place within the more extensively studied late-onset CRC subset. Our aim was to characterize the genomic profiles of these two groups of colorectal tumors and to compare them to each other. Array comparative genomic hybridization profiling of 146 colorectal tumors (60 early-onset and 86 late-onset) in combination with an unsupervised analysis was used to define common and specific copy number alterations. We found a number of important differences between the chromosomal instability profiles of each age subset. Thus, losses at 1p36, 1p12, 1q21, 9p13, 14q11, 16p13, and 16p12 were significantly more frequent in younger patients, whereas gains at 7q11 and 7q22 were more frequent in older patients. Moreover, the unsupervised analysis stratified the tumors into two clusters, each one of which was enriched in patients from one of the age subsets. Our findings confirm the existence of substantial differences between the chromosomal instability profiles of the two groups which are more important from a qualitative point of view. Further studies are needed to understand the clinicopathological implications of these dissimilarities.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Inestabilidad Cromosómica / Hibridación Genómica Comparativa / Variaciones en el Número de Copia de ADN Tipo de estudio: Qualitative_research Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Inestabilidad Cromosómica / Hibridación Genómica Comparativa / Variaciones en el Número de Copia de ADN Tipo de estudio: Qualitative_research Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos