Your browser doesn't support javascript.
loading
The type 3 adenylyl cyclase is required for the survival and maturation of newly generated granule cells in the olfactory bulb.
Luo, Jie; Chen, Xuanmao; Pan, Yung-Wei; Lu, Song; Xia, Zhengui; Storm, Daniel R.
Afiliación
  • Luo J; Department of Pharmacology, University of Washington, Seattle, Washington, United States of America; College of Life Sciences, Wuhan University, Wuhan, Hubei, China.
  • Chen X; Department of Pharmacology, University of Washington, Seattle, Washington, United States of America.
  • Pan YW; Toxicology Program in the Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America.
  • Lu S; Toxicology Program in the Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America.
  • Xia Z; Toxicology Program in the Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America.
  • Storm DR; Department of Pharmacology, University of Washington, Seattle, Washington, United States of America.
PLoS One ; 10(3): e0122057, 2015.
Article en En | MEDLINE | ID: mdl-25807252
The type 3 adenylyl cyclase (AC3) is localized to olfactory cilia in the main olfactory epithelium (MOE) and primary cilia in the adult mouse brain. Although AC3 has been strongly implicated in odor perception and olfactory sensory neuron (OSN) targeting, its role in granule cells (GCs), the most abundant interneurons in the main olfactory bulb (MOB), remains largely unknown. Here, we report that the deletion of AC3 leads to a significant reduction in the size of the MOB as well as the level of adult neurogenesis. The cell proliferation and cell cycle in the subventricular zone (SVZ), however, are not suppressed in AC3-/- mice. Furthermore, AC3 deletion elevates the apoptosis of GCs and disrupts the maturation of newly formed GCs. Collectively, our results identify a fundamental role for AC3 in the development of adult-born GCs in the MOB.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Adenilil Ciclasas Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Adenilil Ciclasas Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos