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Live donor liver transplantation: a valid alternative for critically ill patients suffering from acute liver failure.
Goldaracena, N; Spetzler, V N; Marquez, M; Selzner, N; Cattral, M S; Greig, P D; Lilly, L; McGilvray, I D; Levy, G A; Ghanekar, A; Renner, E L; Grant, D R; Selzner, M.
Afiliación
  • Goldaracena N; Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.
  • Spetzler VN; Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.
  • Marquez M; Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.
  • Selzner N; Department of Medicine, Toronto General Hospital, Toronto, ON, Canada.
  • Cattral MS; Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.
  • Greig PD; Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.
  • Lilly L; Department of Medicine, Toronto General Hospital, Toronto, ON, Canada.
  • McGilvray ID; Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.
  • Levy GA; Department of Medicine, Toronto General Hospital, Toronto, ON, Canada.
  • Ghanekar A; Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.
  • Renner EL; Department of Medicine, Toronto General Hospital, Toronto, ON, Canada.
  • Grant DR; Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.
  • Selzner M; Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.
Am J Transplant ; 15(6): 1591-7, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25799890
We report the outcome of live donor liver transplantation (LDLT) for patients suffering from acute liver failure (ALF). From 2006 to 2013, all patients with ALF who received a LDLT (n = 7) at our institution were compared to all ALF patients receiving a deceased donor liver transplantation (DDLT = 26). Groups were comparable regarding pretransplant ICU stay (DDLT: 1 [0-7] vs. LDLT: 1 days [0-10]; p = 0.38), mechanical ventilation support (DDLT: 69% vs. LDLT: 57%; p = 0.66), inotropic drug requirement (DDLT: 27% vs. LDLT: 43%; p = 0.64) and dialysis (DDLT: 2 vs. LDLT: 0 patients; p = 1). Median evaluation time for live donors was 24 h (18-72 h). LDLT versus DDLT had similar incidence of overall postoperative complications (31% vs. 43%; p = 0.66). No difference was detected between LDLT and DDLT patients regarding 1- (DDLT: 92% vs. LDLT: 86%), 3- (DDLT: 92% vs. LDLT: 86%), and 5- (DDLT: 92% vs. LDLT: 86%) year graft and patient survival (p = 0.63). No severe donor complication (Dindo-Clavien ≥3 b) occurred after live liver donation. ALF is a severe disease with high mortality on liver transplant waiting lists worldwide. Therefore, LDLT is an attractive option since live donor work-up can be expedited and liver transplantation can be performed within 24 h with excellent short- and long-term outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Tejidos / Trasplante de Hígado / Enfermedad Crítica / Fallo Hepático Agudo / Donadores Vivos Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Tejidos / Trasplante de Hígado / Enfermedad Crítica / Fallo Hepático Agudo / Donadores Vivos Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos