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Advances in molecular signaling mechanisms of ß-phenethyl isothiocyanate antitumor effects.
Qin, Chong-Zhen; Zhang, Xue; Wu, Lan-Xiang; Wen, Chun-Jie; Hu, Lei; Lv, Qiao-Li; Shen, Dong-Ya; Zhou, Hong-Hao.
Afiliación
  • Qin CZ; †Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
  • Zhang X; ‡Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, P. R. China.
  • Wu LX; §Institute of Life Sciences, Chongqing Medical University, Chongqing, Chongqing 400016, China.
  • Wen CJ; §Institute of Life Sciences, Chongqing Medical University, Chongqing, Chongqing 400016, China.
  • Hu L; §Institute of Life Sciences, Chongqing Medical University, Chongqing, Chongqing 400016, China.
  • Lv QL; †Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
  • Shen DY; ‡Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, P. R. China.
  • Zhou HH; †Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
J Agric Food Chem ; 63(13): 3311-22, 2015 Apr 08.
Article en En | MEDLINE | ID: mdl-25798652
ß-Phenethyl isothiocyanate (PEITC) is an important phytochemical from cruciferous vegetables and is being evaluated for chemotherapeutic activity in early phase clinical trials. Moreover, studies in cell culture and in animals found that the anticarcinogenic activities of PEITC involved all the major stages of tumor growth: initiation, promotion, and progression. A number of mechanisms have been proposed for the chemopreventive activities of this compound. Here, we focus on the major molecular signaling pathways for the anticancer activities of PEITC. These include (1) activation of apoptosis pathways; (2) induction of cell cycle arrest; and (3) inhibition of the survival pathways. Furthermore, we also discussed the regulation of drug-metabolizing enzymes, including cytochrome P450s, metabolizing enzymes, and multidrug resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Anticarcinógenos / Isotiocianatos / Antineoplásicos Límite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Anticarcinógenos / Isotiocianatos / Antineoplásicos Límite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos