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Voluntary exercise improves metabolic profile in high-fat fed glucocorticoid-treated rats.
Beaudry, Jacqueline L; Dunford, Emily C; Leclair, Erwan; Mandel, Erin R; Peckett, Ashley J; Haas, Tara L; Riddell, Michael C.
Afiliación
  • Beaudry JL; School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, Toronto, Ontario, Canada.
  • Dunford EC; School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, Toronto, Ontario, Canada.
  • Leclair E; School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, Toronto, Ontario, Canada.
  • Mandel ER; School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, Toronto, Ontario, Canada.
  • Peckett AJ; School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, Toronto, Ontario, Canada.
  • Haas TL; School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, Toronto, Ontario, Canada.
  • Riddell MC; School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, Toronto, Ontario, Canada mriddell@yorku.ca.
J Appl Physiol (1985) ; 118(11): 1331-43, 2015 Jun 01.
Article en En | MEDLINE | ID: mdl-25792713
Diabetes is rapidly induced in young male Sprague-Dawley rats following treatment with exogenous corticosterone (CORT) and a high-fat diet (HFD). Regular exercise alleviates insulin insensitivity and improves pancreatic ß-cell function in insulin-resistant/diabetic rodents, but its effect in an animal model of elevated glucocorticoids is unknown. We examined the effect of voluntary exercise (EX) on diabetes development in CORT-HFD-treated male Sprague-Dawley rats (∼6 wk old). Animals were acclimatized to running wheels for 2 wk, then given a HFD, either wax (placebo) or CORT pellets, and split into 4 groups: placebo-sedentary (SED) or -EX and CORT-SED or -EX. After 2 wk of running combined with treatment, CORT-EX animals had reduced visceral adiposity, and increased skeletal muscle type IIb/x fiber area, oxidative capacity, capillary-to-fiber ratio and insulin sensitivity compared with CORT-SED animals (all P < 0.05). Although CORT-EX animals still had fasting hyperglycemia, these values were significantly improved compared with CORT-SED animals (14.3 ± 1.6 vs. 18.8 ± 0.9 mM). In addition, acute in vivo insulin response to an oral glucose challenge was enhanced ∼2-fold in CORT-EX vs. CORT-SED (P < 0.05) which was further demonstrated ex vivo in isolated islets. We conclude that voluntary wheel running in rats improves, but does not fully normalize, the metabolic profile and skeletal muscle composition of animals administered CORT and HFD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Volición / Conducta Animal / Glucemia / Corticosterona / Islotes Pancreáticos / Diabetes Mellitus Experimental / Esfuerzo Físico / Dieta Alta en Grasa / Glucocorticoides / Insulina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Appl Physiol (1985) Asunto de la revista: FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Volición / Conducta Animal / Glucemia / Corticosterona / Islotes Pancreáticos / Diabetes Mellitus Experimental / Esfuerzo Físico / Dieta Alta en Grasa / Glucocorticoides / Insulina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Appl Physiol (1985) Asunto de la revista: FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos