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Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlate with extent of necrotic bowel: results from a multicenter study.
Heida, F H; Hulscher, J B F; Schurink, M; Timmer, A; Kooi, E M W; Bos, A F; Bruggink, J L M; Kasper, D C; Pones, M; Benkoe, T.
Afiliación
  • Heida FH; Department of Pediatric Surgery, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands. Electronic address: f.h.heida@umcg.nl.
  • Hulscher JB; Department of Pediatric Surgery, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Schurink M; Department of Pediatric Surgery, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Timmer A; Department of Pediatric Pathology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Kooi EM; Department of Pediatric Neonatology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Bos AF; Department of Pediatric Neonatology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Bruggink JL; Department of Pediatric Surgery, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Kasper DC; Research Core Unit for Pediatric Biochemistry and Analytics, Medical University of Vienna, Austria.
  • Pones M; Department of Pediatric Surgery, Medical University of Vienna, Austria.
  • Benkoe T; Department of Pediatric Surgery, Medical University of Vienna, Austria.
J Pediatr Surg ; 50(7): 1115-8, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25783297
BACKGROUND: Intestinal fatty acid-binding protein (I-FABP) is considered as a specific marker for enterocyte damage in necrotizing enterocolitis (NEC). OBJECTIVE: The purpose of this study was to evaluate the association of plasma and urinary I-FABP levels with the extent of macroscopic intestinal necrosis in surgical NEC. METHODS: We combined data from prospective trials from two large academic pediatric surgical centers. Nine and 10 infants with surgical NEC were included, respectively. Plasma and urinary of I-FABP at disease onset were correlated with the length of intestinal resection during laparotomy. RESULTS: Median length of bowel resection was 10cm (range 2.5-50) and 17cm (range 0-51), respectively. Median I-FABP levels were 53ng/mL (range 6.3-370) and 4.2ng/mL (range 1.1-15.4) in plasma in cohort 1 respectively cohort 2 and 611ng/mL (range 3-23,336) in urine. The length of bowel resection significantly correlated with I-FABP levels in plasma (Rho 0.68; p=0.04 and Rho 0.66;p=0.04) and in urine (Rho 0.92; p=0.001). CONCLUSION: This 'proof of concept' study demonstrates that plasma and urine I-FABP levels at disease onset was strongly associated with the length of intestinal resection in surgical NEC. This offers further evidence that I-FABP levels are a promising biomarker for assessing intestinal necrosis in infants with advanced NEC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterocolitis Necrotizante / Proteínas de Unión a Ácidos Grasos Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Humans / Infant Idioma: En Revista: J Pediatr Surg Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterocolitis Necrotizante / Proteínas de Unión a Ácidos Grasos Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Humans / Infant Idioma: En Revista: J Pediatr Surg Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos