Your browser doesn't support javascript.
loading
Impact of central surgical review in a study of malignant germ cell tumors.
Billmire, Deborah F; Rescorla, Frederick J; Ross, Jonathan H; Schlatter, Marc G; Dicken, Bryan J; Krailo, Mark D; Rodriguez-Galindo, Carlos; Olson, Thomas A; Cullen, John W; Frazier, A Lindsay.
Afiliación
  • Billmire DF; Department of Surgery, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, United States. Electronic address: dbillmir@iupui.edu.
  • Rescorla FJ; Department of Surgery, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, United States.
  • Ross JH; Division of Urology, Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, OH, United States.
  • Schlatter MG; Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, MI, United States.
  • Dicken BJ; Department of Surgery, University of Alberta, Stollery Childrens Hospital, Edmunton, Alberta, United States.
  • Krailo MD; Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
  • Rodriguez-Galindo C; Dana-Farber Cancer Institute, Boston Childrens Hospital, Boston, MA, United States.
  • Olson TA; Aflac Cancer and Blood Disorders Center, Childrens Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, United States.
  • Cullen JW; Rocky Mountain Hospital for Children, Presbyterian St Luke's Medical, Denver, CO, United States.
  • Frazier AL; Dana-Farber Cancer Institute, Boston Childrens Hospital, Boston, MA, United States.
J Pediatr Surg ; 50(9): 1502-5, 2015 Sep.
Article en En | MEDLINE | ID: mdl-25783295
BACKGROUND: Verification of surgical staging has received little attention in clinical oncology trials. Central surgical review was undertaken during a study of malignant pediatric germ cell tumors. METHODS: Children's Oncology Group study AGCT0132 included central surgical review during the study. Completeness of submitted data and confirmation of assigned stage were assessed. Review responses were: assigned status confirmed, assignment withheld pending review of additional information requested, or institutional assignment of stage disputed with explanation given. Changes in stage assignment were at the discretion of the enrolling institution. RESULTS: A total of 206 patients underwent central review. Failure to submit required data elements or need for clarification was noted in 40%. Disagreement with stage assignment occurred in 10% with 17/21 discordant patients reassigned to stage recommended by central review. Four ovarian tumor patients not meeting review criteria for Stage I remained in that stratum by institutional decision. Two-year event free survival in Stage I ovarian patients was 25% for discordant patients compared to 57% for those meeting Stage I criteria by central review. CONCLUSIONS: Central review of stage assignment improved complete data collection and assignment of correct tumor stage at study entry, and allowed for prompt initiation of chemotherapy in patients determined not to have Stage I disease.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Testiculares / Recolección de Datos / Neoplasias de Células Germinales y Embrionarias Tipo de estudio: Evaluation_studies / Observational_studies / Prognostic_studies Límite: Child / Female / Humans / Male Idioma: En Revista: J Pediatr Surg Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Testiculares / Recolección de Datos / Neoplasias de Células Germinales y Embrionarias Tipo de estudio: Evaluation_studies / Observational_studies / Prognostic_studies Límite: Child / Female / Humans / Male Idioma: En Revista: J Pediatr Surg Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos