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Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation.
Xie, Wensheng; Pariollaud, Marie; Wixted, William E; Chitnis, Nilesh; Fornwald, James; Truong, Maggie; Pao, Christina; Liu, Yan; Ames, Robert S; Callahan, James; Solari, Roberto; Sanchez, Yolanda; Diehl, Alan; Li, Hu.
Afiliación
  • Xie W; Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Pariollaud M; Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • Wixted WE; Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • Chitnis N; Hollings Cancer Center, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America.
  • Fornwald J; Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Truong M; Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Pao C; Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Liu Y; Department of Sample Management Technologies, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Ames RS; Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Callahan J; Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • Solari R; Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.
  • Sanchez Y; Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • Diehl A; Hollings Cancer Center, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America.
  • Li H; Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
PLoS One ; 10(3): e0119738, 2015.
Article en En | MEDLINE | ID: mdl-25780921
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: EIF-2 Quinasa / Factor 2 Relacionado con NF-E2 / Ensayos Analíticos de Alto Rendimiento / Estrés del Retículo Endoplásmico Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: EIF-2 Quinasa / Factor 2 Relacionado con NF-E2 / Ensayos Analíticos de Alto Rendimiento / Estrés del Retículo Endoplásmico Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos