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Genetic structure characterization of Chileans reflects historical immigration patterns.
Eyheramendy, Susana; Martinez, Felipe I; Manevy, Federico; Vial, Cecilia; Repetto, Gabriela M.
Afiliación
  • Eyheramendy S; Department of Statistics, Facultad de Matemáticas, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, Macul, Santiago 6904411, Chile.
  • Martinez FI; Interdisciplinary Center for Intercultural and Indigenous Studies, Anthropology Program, Institute of Sociology, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, Macul, Santiago 6904411, Chile.
  • Manevy F; Department of Statistics, Facultad de Matemáticas, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, Macul, Santiago 6904411, Chile.
  • Vial C; 1] Center for Genetics and Genomics, Facultad de Medicina, Clinica Alemana, Universidad del Desarrollo, Av. Las Condes 12438, Lo Barnechea, Santiago 7710162, Chile [2] Hantavirus Program, Facultad de Medicina, Clinica Alemana Universidad del Desarrollo, Las Condes 12438, Lo Barnechea, Santiago 77101
  • Repetto GM; Center for Genetics and Genomics, Facultad de Medicina, Clinica Alemana, Universidad del Desarrollo, Av. Las Condes 12438, Lo Barnechea, Santiago 7710162, Chile.
Nat Commun ; 6: 6472, 2015 Mar 17.
Article en En | MEDLINE | ID: mdl-25778948
Identifying the ancestral components of genomes of admixed individuals helps uncovering the genetic basis of diseases and understanding the demographic history of populations. We estimate local ancestry on 313 Chileans and assess the contribution from three continental populations. The distribution of ancestry block-length suggests an average admixing time around 10 generations ago. Sex-chromosome analyses confirm imbalanced contribution of European men and Native-American women. Previously known genes under selection contain SNPs showing large difference in allele frequencies. Furthermore, we show that assessing ancestry is harder at SNPs with higher recombination rates and easier at SNPs with large difference in allele frequencies at the ancestral populations. Two observations, that African ancestry proportions systematically decrease from North to South, and that European ancestry proportions are highest in central regions, show that the genetic structure of Chileans is under the influence of a diffusion process leading to an ancestry gradient related to geography.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Emigración e Inmigración / Genética de Población Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: America do sul / Chile / Europa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Emigración e Inmigración / Genética de Población Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: America do sul / Chile / Europa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Reino Unido