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The significance of allergic contact urticaria to milk in children with cow's milk allergy.
Schichter-Konfino, Vered; Almog, Meital; Bamberger, Ellen; Berkowitz, Drora; Kessel, Aharon.
Afiliación
  • Schichter-Konfino V; Division of Allergy & Clinical Immunology, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Almog M; Division of Allergy & Clinical Immunology, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Bamberger E; Pediatric Department, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Berkowitz D; Pediatric Gastroenterology Unit, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Kessel A; Division of Allergy & Clinical Immunology, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Pediatr Allergy Immunol ; 26(3): 218-222, 2015 May.
Article en En | MEDLINE | ID: mdl-25775957
BACKGROUND: Cow's milk allergy (CMA) is the most common food allergy in infancy. Food allergy is generally triggered through ingestion, but can also be triggered through skin contact. We investigated the incidence and the clinical significance of cow's milk protein (CMP)-induced contact urticaria in individuals with CMA with and without atopic dermatitis (AD). METHODS: A total of 157 children of whom 133 were diagnosed with CMA were participated. The study was based on observational data gathered in the course of patient care, including a skin prick test and a 'finger test', in which cow's milk is applied on the cheek by a physician's finger to detect contact urticaria. RESULTS: Eighty nine of 133 patients (66.9%) had IgE-mediated CMA. Forty of these 89 (44.9%) tested positive in the finger test. Family atopy was higher in those with positive contact urticaria [21/40 (52.5%) vs. 14/49 (28.5%), p = 0.029]. Patients with positive vs. negative CMP contact urticaria had higher incidence of multiple food allergies [20 of 40 (50%) vs. 7/49 (14.3%), p < 0.004]. IgE-mediated CMA patients with AD had statistically higher CMP allergic contact urticaria compared to patients without AD [71% (15/21) vs. 37% (25/68), p = 0.0064]. Children with non-IgE milk allergy and healthy control group did not have contact urticaria to CMP. CONCLUSION: CMP contact urticaria exists only in patients with IgE-mediated CMA. A 'finger test' to CMP should be part of the evaluation of CMA patients, and positivity suggests the potential for multiple food allergies, especially to sesame and egg.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Urticaria / Hipersensibilidad a la Leche / Dermatitis Alérgica por Contacto / Dermatitis Atópica Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies Límite: Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Pediatr Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / PEDIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Urticaria / Hipersensibilidad a la Leche / Dermatitis Alérgica por Contacto / Dermatitis Atópica Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies Límite: Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Pediatr Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / PEDIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido