Esterase activity of carbonic anhydrases serves as surrogate for selecting antibodies blocking hydratase activity.

Uda, Narasimha Rao; Seibert, Volker; Stenner-Liewen, Frank; Müller, Philipp; Herzig, Petra; Gondi, Gabor; Zeidler, Reinhard; van Dijk, Marc; Zippelius, Alfred; Renner, Christoph

Uda, Narasimha Rao; Seibert, Volker; Stenner-Liewen, Frank; Müller, Philipp; Herzig, Petra; Gondi, Gabor; Zeidler, Reinhard; van Dijk, Marc; Zippelius, Alfred; Renner, Christoph.

Afiliación

Uda NR; a Department of Biomedicine , University of Basel , Basel , Switzerland .
Seibert V; b 4-Antibody AG (Wholly-Owned Subsidiary of Agenus Inc., USA) , Basel , Switzerland .
Stenner-Liewen F; a Department of Biomedicine , University of Basel , Basel , Switzerland .
Müller P; c Department Internal Medicine , University Hospital Basel , Basel , Switzerland .
Herzig P; a Department of Biomedicine , University of Basel , Basel , Switzerland .
Gondi G; a Department of Biomedicine , University of Basel , Basel , Switzerland .
Zeidler R; d Department of Otorhinolaryngology , Klinikum der Universität München , Munich , Germany , and.
van Dijk M; e Helmholtz Zentrum München - German Research Center for Environmental Health, Research Unit Gene Vectors , Munich , Germany.
Zippelius A; d Department of Otorhinolaryngology , Klinikum der Universität München , Munich , Germany , and.
Renner C; e Helmholtz Zentrum München - German Research Center for Environmental Health, Research Unit Gene Vectors , Munich , Germany.

J Enzyme Inhib Med Chem ; 30(6): 955-60, 2015 Dec.

Article en En | MEDLINE | ID: mdl-25775095

Asunto(s)

Aconitato Hidratasa/antagonistas & inhibidores; Anticuerpos Monoclonales/farmacología; Antígenos de Neoplasias/metabolismo; Anhidrasas Carbónicas/metabolismo; Inhibidores Enzimáticos/farmacología; Esterasas/metabolismo; Acetazolamida/química; Acetazolamida/farmacología; Aconitato Hidratasa/metabolismo; Anticuerpos Monoclonales/química; Anhidrasa Carbónica IX; Relación Dosis-Respuesta a Droga; Inhibidores Enzimáticos/química; Humanos; Estructura Molecular; Relación Estructura-Actividad

Palabras clave

Cancer therapy; carbonic anhydrase 9 & 12; enzyme inhibition; high-throughput screening; renal cell cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aconitato Hidratasa / Anhidrasas Carbónicas / Inhibidores Enzimáticos / Esterasas / Anticuerpos Monoclonales / Antígenos de Neoplasias Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

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