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ROCK2 promotes HCC proliferation by CEBPD inhibition through phospho-GSK3ß/ß-catenin signaling.
Li, Ming; Zhou, Wei; Yuan, Rongfa; Chen, Leifeng; Liu, Tiande; Huang, Da; Hao, Liang; Xie, Yuancai; Shao, Jianghua.
Afiliación
  • Li M; Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
  • Zhou W; Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; Department of Gastrointestinal Surgery, Jiangxi Provincial Cancer Hospital, Nanchang 330029, China.
  • Yuan R; Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; Jiangxi Province Engineering Research Center of Hepatobiliary Disease, Nanchang 330006, China.
  • Chen L; Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
  • Liu T; Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; Jiangxi Province Engineering Research Center of Hepatobiliary Disease, Nanchang 330006, China.
  • Huang D; Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
  • Hao L; Jiangxi Province Key Laboratory of Molecular Medicine, Nanchang 330006, China.
  • Xie Y; Department of Hepatobiliary Surgery, Ganzhou People's Hospital, Jiangxi Province 34100 China.
  • Shao J; Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; Jiangxi Province Engineering Research Center of Hepatobiliary Disease, Nanchang 330006, China; Jiangxi Province Key Laboratory of Molecular Medicine, Nanchang 330006, China. Electronic address:
FEBS Lett ; 589(9): 1018-25, 2015 Apr 13.
Article en En | MEDLINE | ID: mdl-25771860
Rho-associated kinase 2 (Rock2) is known to promote tumorigenesis in hepatocellular carcinoma (HCC). CCAAT/enhancer-binding protein delta (CEBPD) functions as a tumor suppressor. In this study, we found that the expression of Rock2 and CEBPD are inversely correlated. Knockdown of Rock2 increased CEBPD expression and inhibited the proliferation of HCC cells in vitro and in vivo. Mechanistically, we found that Rock2 regulates CEBPD expression through the p-GSK3ß/ß-catenin pathway. Taken together, we identified a novel Rock2-p-GSK3ß/ß-catenin-CEBPD regulatory circuitry, the dysfunction of which may contribute to the tumorigenic characteristic of HCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Glucógeno Sintasa Quinasa 3 / Proliferación Celular / Beta Catenina / Proteína delta de Unión al Potenciador CCAAT / Quinasas Asociadas a rho Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: FEBS Lett Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Glucógeno Sintasa Quinasa 3 / Proliferación Celular / Beta Catenina / Proteína delta de Unión al Potenciador CCAAT / Quinasas Asociadas a rho Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: FEBS Lett Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido