Your browser doesn't support javascript.
loading
Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk.
Farr, O M; Ko, B-J; Joung, K E; Zaichenko, L; Usher, N; Tsoukas, M; Thakkar, B; Davis, C R; Crowell, J A; Mantzoros, C S.
Afiliación
  • Farr OM; Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: ofarr@bidmc.harvard.edu.
  • Ko BJ; Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Joung KE; Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Zaichenko L; Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Usher N; Judge Baker Children's Center, Boston, MA 02120, USA.
  • Tsoukas M; Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Thakkar B; Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Cente
  • Davis CR; Judge Baker Children's Center, Boston, MA 02120, USA.
  • Crowell JA; Judge Baker Children's Center, Boston, MA 02120, USA; Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, NY, USA.
  • Mantzoros CS; Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nutr Metab Cardiovasc Dis ; 25(5): 479-88, 2015 May.
Article en En | MEDLINE | ID: mdl-25770759
BACKGROUND AND AIMS: There is some evidence that posttraumatic stress disorder (PTSD) and early life adversity may influence metabolic outcomes such as obesity, diabetes, and cardiovascular disease. However, whether and how these interact is not clear. METHODS: We analyzed data from a cross-sectional and longitudinal study to determine how PTSD severity influences obesity, insulin sensitivity, and key measures and biomarkers of cardiovascular risk. We then looked at how PTSD and early life adversity may interact to impact these same outcomes. RESULTS: PTSD severity is associated with increasing risk of obesity, diabetes, and cardiovascular disease, with higher symptoms correlating with higher values of BMI, leptin, fibrinogen, and blood pressure, and lower values of insulin sensitivity. PTSD and early life adversity have an additive effect on these metabolic outcomes. The longitudinal study confirmed findings from the cross sectional study and showed that fat mass, leptin, CRP, sICAM-1, and sTNFRII were significantly increased with higher PTSD severity during a 2.5 year follow-up period. CONCLUSIONS: Individuals with early life adversity and PTSD are at high risk and should be monitored carefully for obesity, insulin resistance, and cardiometabolic risk.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Enfermedades Cardiovasculares / Desarrollo Infantil / Síndrome Metabólico / Diabetes Mellitus / Acontecimientos que Cambian la Vida / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies País/Región como asunto: America do norte Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Enfermedades Cardiovasculares / Desarrollo Infantil / Síndrome Metabólico / Diabetes Mellitus / Acontecimientos que Cambian la Vida / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies País/Región como asunto: America do norte Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos