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Enteral topiramate in a pediatric patient with refractory status epilepticus: a case report and review of the literature.
Shelton, Chasity M; Alford, Elizabeth L; Storgion, Stephanie; Wheless, James; Phelps, Stephanie J.
Afiliación
  • Shelton CM; Department of Clinical Pharmacy, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee.
  • Alford EL; Department of Clinical Pharmacy, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee.
  • Storgion S; Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee.
  • Wheless J; Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee ; Neuroscience Institute and Le Bonheur Comprehensive Epilepsy Program, Le Bonheur Children's Hospital, Memphis, Tennessee.
  • Phelps SJ; Department of Clinical Pharmacy, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee ; Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee.
J Pediatr Pharmacol Ther ; 19(4): 317-24, 2014.
Article en En | MEDLINE | ID: mdl-25762878
We describe the use of topiramate in a healthy 12-year-old (88-kg) male who developed refractory generalized convulsive status epilepticus. Seizures persisted despite aggressive use of benzodiazepines (intravenous lorazepam; oral clorazepate), barbiturates (i.e., phenobarbital, pentobarbital), and hydantoins. The child's seizures were controlled with nasogastrically administered topiramate in doses up to 500 mg twice daily (11.4 mg/kg/day). The patient did not display any clinical or laboratory signs of metabolic acidosis while receiving topiramate. Topiramate should be considered as a treatment option in refractory status epilepticus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Pediatr Pharmacol Ther Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Pediatr Pharmacol Ther Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos