Enhancing glucose sensor models: modeling the drop-outs.
Diabetes Technol Ther
; 17(6): 420-6, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25751260
BACKGROUND: Computer simulation environments have been used in the development of many artificial pancreas systems. A glucose sensor model is an essential part of these environments, and different models have been proposed. However, not one of these models accounts for drop-outs of sensor readings, a well-known phenomenon caused by physical pressure on the sensor site. In this work, we have proposed an enhanced model that accounts for drop-outs and demonstrated its improvement over the existing one-compartment model. MATERIALS AND METHODS: Potential drop-outs were augmented to the existing model, and their incidences and magnitudes were estimated simultaneously with the model parameters using the Bayesian approach. Drop-outs and model parameters were estimated from data collected from 15 subjects with type 1 diabetes who underwent an artificial pancreas study. Model fitting and parameter estimates were contrasted between the enhanced model and the existing one-compartment model. RESULTS: Both models achieved similar parameter estimates (P=not significant) and were all physiologically plausible. The enhanced model further estimated 1.71 drop-outs per day, which improved model fit (weighted residual reduced from [minimum -4%, maximum 3%] to [-3%, 2%]) and reduced significantly the deviance information criteria from 2739.72 to 1456.00. CONCLUSIONS: The enhanced model improves fitting of glucose levels and should allow more realistic simulations that assesses artificial pancreas systems.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glucemia
/
Modelos Estadísticos
/
Páncreas Artificial
/
Diabetes Mellitus Tipo 1
/
Modelos Biológicos
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Diabetes Technol Ther
Asunto de la revista:
ENDOCRINOLOGIA
/
TERAPEUTICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos