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An in vivo swine study for xeno-grafts of calcium sulfate-based bone grafts with human dental pulp stem cells (hDPSCs).
Kuo, Tzong-fu; Lee, Sheng-Yang; Wu, Hong-Da; Poma, Malosi; Wu, Yu-Wei; Yang, Jen-Chang.
Afiliación
  • Kuo TF; Department of Veterinary Medicine, National Taiwan University, Taipei 110, Taiwan, ROC; Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 110, Taiwan, ROC.
  • Lee SY; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC; Dental Department, Wan-Fang Hospital, Taipei Medical University, Taipei 110, Taiwan, ROC; Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 110, Taiwan, ROC.
  • Wu HD; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC.
  • Poma M; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC.
  • Wu YW; Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 110, Taiwan, ROC.
  • Yang JC; Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 110, Taiwan, ROC; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC. Electronic address: yang820065@tmu.edu.tw.
Mater Sci Eng C Mater Biol Appl ; 50: 19-23, 2015 May.
Article en En | MEDLINE | ID: mdl-25746240
The purpose of this in vivo study was to evaluate the effect of human dental pulp stem cells (hDPSCs) on various resorbable calcium sulfate/calcium phosphate bone grafts in bone regeneration. Granular particles of calcium sulfate dehydrate (CSD), α-calcium sulfate hemihydrate/amorphous calcium phosphate (α-CSH/ACP), and CSD/ß-tricalcium phosphates (ß-TCP) were prepared for in vitro dissolution and implantation test. The chemical compositions of specimen residues after dissolution test were characterized by XRD. The ratios of new bone formation for implanted grafts/hDPSCs were evaluated using mandible bony defect model of Lanyu pig. All the graft systems exhibited a similar two-stage dissolution behavior and phase transformation of poor crystalline HAp. Eight weeks post-operation, the addition of hDPSCs to various graft systems showed statistically significant increasing in the ratio of new bone formation (p<0.05). Null hypothesis of hDPSCs showing no scaffold dependence in bone regeneration was rejected. The results suggest that the addition of hDPSCs to calcium sulfate based xenografts could enhance the bone regeneration in the bony defect.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Trasplante Heterólogo / Sulfato de Calcio / Trasplante Óseo / Trasplante de Células Madre / Pulpa Dental Límite: Animals / Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Trasplante Heterólogo / Sulfato de Calcio / Trasplante Óseo / Trasplante de Células Madre / Pulpa Dental Límite: Animals / Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos