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Placental expression of adenosine A(2A) receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system.
Kurlak, L O; Williams, P J; Bulmer, J N; Broughton Pipkin, F; Mistry, H D.
Afiliación
  • Kurlak LO; Department of Obstetrics & Gynaecology, School of Medicine, University of Nottingham, NG5 1PB, UK. Electronic address: Lesia.kurlak@nottingham.ac.uk.
  • Williams PJ; School of Veterinary Medicine & Science, Faculty of Medicine and Health Science, University of Nottingham, LE12 5RD, UK.
  • Bulmer JN; Institute of Cellular Medicine, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
  • Broughton Pipkin F; Department of Obstetrics & Gynaecology, School of Medicine, University of Nottingham, NG5 1PB, UK.
  • Mistry HD; Division of Hypertension, Department of Nephrology, Hypertension and Clinical Pharmacology, University of Bern, Berne CH-3010, Switzerland.
Placenta ; 36(5): 611-3, 2015 May.
Article en En | MEDLINE | ID: mdl-25745823
Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) promote angiogenesis and vascularisation. We investigated the temporal expression placental adenosine A2AR receptor and HIF-1α in early pregnancy and at delivery in normotensive (NT) and pre-eclamptic (PE) women. Results were compared to our previously reported angiotensin receptor data. Expression of A2AR and HIF-1α was highest at ≤10 weeks, positively correlated through pregnancy and was higher in PE than NT at delivery. The A2AR associated with the AT4R only in early pregnancy. We suggest adenosine and RAS may interact to promote placentation with a potential adaptation to poor placental perfusion in PE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Preeclampsia / Primer Trimestre del Embarazo / Receptor de Adenosina A2A / Subunidad alfa del Factor 1 Inducible por Hipoxia Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Placenta Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Preeclampsia / Primer Trimestre del Embarazo / Receptor de Adenosina A2A / Subunidad alfa del Factor 1 Inducible por Hipoxia Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Placenta Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos