Your browser doesn't support javascript.
loading
Prospective validation of DACH2 as a novel biomarker for prediction of metastasis and prognosis in muscle-invasive urothelial carcinoma of the bladder.
He, Ya-Di; Luo, Zi-Huan; Yang, Ming; Ruan, Xing-Xing; Liu, Shao-Yuan; Wu, Zhen-Quan; Deng, Wei-Ming; Shao, Chun-Kui; Su, Zu-Lan; He, Dan; Gao, Xin; Li, Liao-Yuan.
Afiliación
  • He YD; Center of Health Care, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
  • Luo ZH; Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
  • Yang M; Department of Urology, Foshan Hospital of Traditional Medicine, Foshan, 528000, China.
  • Ruan XX; Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
  • Liu SY; Department of Urology, Foshan First Municipal People's Hospital, Sun Yat-sen University, Foshan, 528000, China.
  • Wu ZQ; Department of Urology, Foshan First Municipal People's Hospital, Sun Yat-sen University, Foshan, 528000, China.
  • Deng WM; Department of Urology, The First Affiliated Hospital, University of South China, Hengyang, 421000, China.
  • Shao CK; Department of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
  • Su ZL; Department of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
  • He D; Department of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
  • Gao X; Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
  • Li LY; Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China. Electronic address: liliao10318023@126.com.
Biochem Biophys Res Commun ; 459(3): 416-23, 2015 Apr 10.
Article en En | MEDLINE | ID: mdl-25744029
Metastasis is the main cause of death from muscle-invasive urothelial carcinoma of the bladder (UCB), and the metastatic potential of tumors is often unpredictable. The role of Dachshund homolog 2 gene (DACH2) in tumorigenesis remains unexplored. We aimed to investigate whether DACH2 can be used as a biomarker to predict metastasis and prognosis of muscle-invasive UCB in a sequential training and validation fashion. For the training set (n = 40), compared with UCB patients without lymph node (LN) metastasis, both DACH2 protein and mRNA expression were greatly increased in case-matched patients with LN metastasis. For the independent validation set (n = 243), patients with primary UCB that did not express DACH2 had a longer metastasis-free survival (MFS) and overall survival (OS) than did those with tumors expressing DACH2 (5-year MFS: 88% [95% CI 80-96] versus 19% [95% CI 7-31], p < 0.001; 5-year OS: 93% [95% CI 87-99] versus 37% [95% CI 23-51], p < 0.001). Multivariable analysis of DACH2 status showed hazard ratios of 7.34 (95% CI 3.15-11.87, p < 0.001) for MFS and 3.96 (95% CI 2.04-7.16, p < 0.001) for OS which were much higher than hazard ratios associated with other independent risk factors. Collectively, DACH2 is an independent prognostic marker that can be used at initial diagnosis of UCB to identify patients who have a high potential to develop metastasis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Neoplasias de la Vejiga Urinaria / Proteínas Nucleares / Biomarcadores de Tumor Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biochem Biophys Res Commun Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Neoplasias de la Vejiga Urinaria / Proteínas Nucleares / Biomarcadores de Tumor Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biochem Biophys Res Commun Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos