[The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats].
Izv Akad Nauk Ser Biol
; (6): 616-20, 2014.
Article
en Ru
| MEDLINE
| ID: mdl-25739310
Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
/
Dexametasona
/
Cerebelo
/
Caspasa 3
/
Glucocorticoides
/
Hipoxia
Límite:
Animals
Idioma:
Ru
Revista:
Izv Akad Nauk Ser Biol
Asunto de la revista:
BIOLOGIA
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Rusia