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A novel tacrine-dihydropyridine hybrid (-)SCR1693 induces tau dephosphorylation and inhibits Aß generation in cells.
Wang, Xiu-Lian; Xiong, Yan; Yang, Yang; Tuo, Qing-Zhang; Wang, Xiao-Chuan; Chen, Rong; Tian, Qing; Zhang, Zheng-Ping; Yan, Xiong; Yang, Zhang-Yuan; Wang, Jian-Zhi; Liu, Rong.
Afiliación
  • Wang XL; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China;
  • Xiong Y; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China;
  • Yang Y; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Tuo QZ; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wang XC; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chen R; Jiangsu Simovay Pharmaceutical Co., Ltd., Nanjing, China.
  • Tian Q; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang ZP; Jiangsu Simovay Pharmaceutical Co., Ltd., Nanjing, China.
  • Yan X; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yang ZY; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wang JZ; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: wangjz@mails.tjmu.edu.cn.
  • Liu R; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: rong.liu@hust.edu.cn.
Eur J Pharmacol ; 754: 134-9, 2015 May 05.
Article en En | MEDLINE | ID: mdl-25732864

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tacrina / Péptidos beta-Amiloides / Proteínas tau Límite: Animals / Humans Idioma: En Revista: Eur J Pharmacol Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tacrina / Péptidos beta-Amiloides / Proteínas tau Límite: Animals / Humans Idioma: En Revista: Eur J Pharmacol Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos