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Interleukin-10 and tumour necrosis factor-alpha serum levels in chronic Chagas disease patients.
Vasconcelos, R H T; Azevedo, E de A N; Diniz, G T N; Cavalcanti, M da G A de M; de Oliveira, W; de Morais, C N L; Gomes, Y de M.
Afiliación
  • Vasconcelos RH; Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Pernambuco, Brazil.
  • Azevedo Ede A; Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Pernambuco, Brazil.
  • Diniz GT; Departamento de Saúde Coletiva, Centro de Pesquisas Aggeu Magalhães, Pernambuco, Brazil.
  • Cavalcanti Mda G; Ambulatório de Doença de Chagas e Insuficiência Cardíaca - PROCAPE, Universidade de Pernambuco, Pernambuco, Brazil.
  • de Oliveira W; Ambulatório de Doença de Chagas e Insuficiência Cardíaca - PROCAPE, Universidade de Pernambuco, Pernambuco, Brazil.
  • de Morais CN; Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Pernambuco, Brazil.
  • Gomes Yde M; Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Pernambuco, Brazil.
Parasite Immunol ; 37(7): 376-9, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25728555
In Chagas disease, chronically infected individuals may be asymptomatic or may present cardiac or digestive complications, and it is well known that the human immune response is related to different clinical manifestations. Different patterns of cytokine levels have been previously described in different clinical forms of this disease, but contradictory results are reported. Our aim was to evaluate the serum levels of interleukin-10 and tumour necrosis factor-alpha in patients with asymptomatic and cardiac Chagas disease. The serum interleukin-10 levels in patients with cardiomyopathy were higher than those in asymptomatic patients, mainly in those without heart enlargement. Although no significant difference was observed in serum tumour necrosis factor-alpha levels among the patients, we found that cardiac patients also present high levels of this cytokine, largely those with heart dilatation. Therefore, these cytokines play an important role in chronic Chagas disease cardiomyopathy. Follow-up investigations of these and other cytokines in patients with chronic Chagas disease need to be conducted to improve the understanding of the immunopathology of this disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiomiopatía Chagásica / Factor de Necrosis Tumoral alfa / Interleucina-10 Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Parasite Immunol Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiomiopatía Chagásica / Factor de Necrosis Tumoral alfa / Interleucina-10 Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Parasite Immunol Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido