A surface plasmon resonance assay for measurement of neuraminidase inhibition, sensitivity of wild-type influenza neuraminidase and its H274Y mutant to the antiviral drugs zanamivir and oseltamivir.

Somasundaram, Balaji; Fee, Conan J; Fredericks, Rayleen; Watson, Andrew J A; Fairbanks, Antony J; Hall, Richard J

Somasundaram, Balaji; Fee, Conan J; Fredericks, Rayleen; Watson, Andrew J A; Fairbanks, Antony J; Hall, Richard J.

Afiliación

Somasundaram B; Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand.
Fee CJ; Chemical and Process Engineering, University of Canterbury, Private Bag 4800, 8140, Christchurch, Canterbury, New Zealand.
Fredericks R; Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand.
Watson AJ; Chemical and Process Engineering, University of Canterbury, Private Bag 4800, 8140, Christchurch, Canterbury, New Zealand.
Fairbanks AJ; Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand.
Hall RJ; Chemical and Process Engineering, University of Canterbury, Private Bag 4800, 8140, Christchurch, Canterbury, New Zealand.

J Mol Recognit ; 28(9): 521-7, 2015 Sep.

Article en En | MEDLINE | ID: mdl-25727669

Asunto(s)

Antivirales/farmacología; Inhibidores Enzimáticos/metabolismo; Gripe Humana/tratamiento farmacológico; Neuraminidasa/antagonistas & inhibidores; Oseltamivir/farmacología; Resonancia por Plasmón de Superficie; Zanamivir/farmacología; Animales; Antivirales/química; Línea Celular; Humanos; Gripe Humana/genética; Gripe Humana/metabolismo; Gripe Humana/virología; Concentración 50 Inhibidora; Insectos/citología; Mutación; Neuraminidasa/metabolismo; Oseltamivir/química; Zanamivir/química

Palabras clave

antiviral drugs; drug resistance; influenza neuraminidase; inhibition assay; surface plasmon resonance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Resonancia por Plasmón de Superficie / Inhibidores Enzimáticos / Gripe Humana / Oseltamivir / Zanamivir / Neuraminidasa Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: J Mol Recognit Asunto de la revista: BIOLOGIA MOLECULAR Año: 2015 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido

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