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Increased premotor cortex activation in high functioning autism during action observation.
Perkins, Tom J; Bittar, Richard G; McGillivray, Jane A; Cox, Ivanna I; Stokes, Mark A.
Afiliación
  • Perkins TJ; Department of Psychology, Faculty of Health, Deakin University, Burwood, VIC, Australia.
  • Bittar RG; Department of Psychology, Faculty of Health, Deakin University, Burwood, VIC, Australia; Department of Neurosurgery, Royal Melbourne Hospital, Parkville, VIC, Australia; Precision Brain Spine and Pain Centre, Melbourne, VIC, Australia. Electronic address: profbittar@precisionhealth.com.au.
  • McGillivray JA; Department of Psychology, Faculty of Health, Deakin University, Burwood, VIC, Australia.
  • Cox II; Department of Psychology, Faculty of Health, Deakin University, Burwood, VIC, Australia.
  • Stokes MA; Department of Psychology, Faculty of Health, Deakin University, Burwood, VIC, Australia.
J Clin Neurosci ; 22(4): 664-9, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25726458
The mirror neuron (MN) hypothesis of autism has received considerable attention, but to date has produced inconsistent findings. Using functional MRI, participants with high functioning autism or Asperger's syndrome were compared to typically developing individuals (n=12 in each group). Participants passively observed hand gestures that included waving, pointing, and grasping. Concerning the MN network, both groups activated similar regions including prefrontal, inferior parietal and superior temporal regions, with the autism group demonstrating significantly greater activation in the dorsal premotor cortex. Concerning other regions, participants with autism demonstrated increased activity in the anterior cingulate and medial frontal gyrus, and reduced activation in calcarine, cuneus, and middle temporal gyrus. These results suggest that during observation of hand gestures, frontal cortex activation is affected in autism, which we suggest may be linked to abnormal functioning of the MN system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Corteza Motora Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J Clin Neurosci Asunto de la revista: NEUROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Corteza Motora Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J Clin Neurosci Asunto de la revista: NEUROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido