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Preconditioning with mono and polyunsaturated fatty acids and low-intensity electrical stimulation. Effects on skin repair in rats.
Cardoso, Maria dos Prazeres Carneiro; Albuquerque, Andréa de Oliveira; Girão, Virginia Claudia Carneiro; Pompeu, Margarida Maria de Lima; Silva, Cícero Igor Simões Moura; Azevedo, Orleâncio Gomes Ritardo de; Guimarães, Sergio Botelho; Vasconcelos, Paulo Roberto Leitão de.
Afiliación
  • Cardoso Mdos P; Postgraduate Program in Surgery, Department of Surgery, UFC, Ceara, Brazil.
  • Albuquerque Ade O; Nursing School, UFC, Ceara, Brazil.
  • Girão VC; Department of Morphology, Faculty of Medicine, UFC, Ceara, Brazil.
  • Pompeu MM; Department of Morphology, Faculty of Medicine, UFC, Ceara, Brazil.
  • Silva CI; Department of Morphology, Faculty of Medicine, UFC, Ceara, Brazil.
  • Azevedo OG; Laboratory of Ontogeny and Nutrition of Tissue Healing, Institute of Biomedicine of the Brazilian Semi Arid, UFC, Ceara, Brazil.
  • Guimarães SB; Department of Surgery, Surgical Research Laboratory, UFC, Ceara, Brazil.
  • Vasconcelos PR; Postgraduate Program in Surgery, Department of Surgery, UFC, Ceara, Brazil.
Acta Cir Bras ; 30(2): 107-14, 2015 Feb.
Article en En | MEDLINE | ID: mdl-25714689
PURPOSE: To evaluate the effects of preconditioning with oils mixes containing ω3/ω6/ω9 associated with micro-currents on skin repair in rats. METHODS: One-hundred and eight Wistar rats randomized into G-1, G-2 and G-3 groups were treated with saline (0.9%), mix 1 (corn+soybean oils) and mix 2 (olive+canola+flaxseed oils), respectively, in a single dose (0.01ml/g) by gavage. Next, each group was subdivided into sham and stimulated subgroups. Pulsed-wave microcurrents (0.5 µA, 0.5 Hz) were applied to stimulated subgroups for 20 min. One hour later anesthetized rats were subjected to surgery. A dorsal incision (6 cm long) was carried out and closed with interrupted nylon sutures. Samples (1 cm2) were harvested from the mid-portion of the incision on the 7, 14, 21 post-operative (P.O.) days. Variables were analyzed using Mann-Whitney/Dunn tests Significance level was set to 5 % (p<0.05). RESULTS: Micro-currents promoted increase of exudate and reduction of epithelialization on day 7 in G1 rats. Mixes 1/2 reduced vascularization on 7/14th days P.O. Both 1/2 mixes reduced fibrosis on day 14. Preconditioning with mix 1 led to increased expression of NF-kB on the 7th day. CONCLUSION: Preconditioning with microcurrents has pro-inflammatory effects while oil mixes 1 and 2 decrease fibrosis and vascularization in the proliferative phase of cicatrization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Cicatrización de Heridas / Ácidos Grasos Monoinsaturados / Terapia por Estimulación Eléctrica / Ácidos Grasos Insaturados Tipo de estudio: Evaluation_studies Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Cicatrización de Heridas / Ácidos Grasos Monoinsaturados / Terapia por Estimulación Eléctrica / Ácidos Grasos Insaturados Tipo de estudio: Evaluation_studies Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil