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Magnetic nanoparticle-supported lipid bilayers for drug delivery.
Mattingly, Stephanie J; O'Toole, Martin G; James, Kurtis T; Clark, Geoffrey J; Nantz, Michael H.
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  • Mattingly SJ; †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
  • O'Toole MG; †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
  • James KT; †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
  • Clark GJ; †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
  • Nantz MH; †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
Langmuir ; 31(11): 3326-32, 2015 Mar 24.
Article en En | MEDLINE | ID: mdl-25714501
Magnetic nanoparticle-supported lipid bilayers (SLBs) constructed around core-shell Fe3O4-SiO2 nanoparticles (SNPs) were prepared and evaluated as potential drug carriers. We describe how an oxime ether lipid can be mixed with SNPs to produce lipid-particle assemblies with highly positive ζ potential. To demonstrate the potential of the resultant cationic SLBs, the particles were loaded with either the anticancer drug doxorubicin or an amphiphilic analogue, prepared to facilitate integration into the supported lipid bilayer, and then examined in studies against MCF-7 breast cancer cells. The assemblies were rapidly internalized and exhibited higher toxicity than treatments with doxorubicin alone. The magnetic SLBs were also shown to increase the efficacy of unmodified doxorubicin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Nanopartículas de Magnetita / Membrana Dobles de Lípidos / Antineoplásicos Límite: Humans Idioma: En Revista: Langmuir Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Nanopartículas de Magnetita / Membrana Dobles de Lípidos / Antineoplásicos Límite: Humans Idioma: En Revista: Langmuir Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos