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High-level expression of Hsp90ß is associated with poor survival in resectable non-small-cell lung cancer patients.
Kim, Seok-Hyun; Ji, Jun Ho; Park, Kyung Tae; Lee, Ji Hyun; Kang, Kyung Woo; Park, Jae Hong; Hwang, Sang Won; Lee, Eun Hee; Cho, Yu Ji; Jeong, Yi Yeong; Kim, Ho-Cheol; Lee, Jong Deog; Jang, Inseok; Lee, Jong Sil; Lee, Hyoun Wook; Lee, Gyeong-Won.
Afiliación
  • Kim SH; Division of Haematology and Medical Oncology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • Ji JH; Division of Haematology and Medical Oncology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • Park KT; Division of Haematology and Medical Oncology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • Lee JH; Division of Pulmonology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • Kang KW; Division of Pulmonology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • Park JH; Department of Thoracic and Cardiovascular Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • Hwang SW; Department of Thoracic and Cardiovascular Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • Lee EH; Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • Cho YJ; Division of Pulmonology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.
  • Jeong YY; Division of Pulmonology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.
  • Kim HC; Division of Pulmonology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.
  • Lee JD; Division of Pulmonology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.
  • Jang I; Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University School of Medicine, Jinju, Korea.
  • Lee JS; Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Korea.
  • Lee HW; Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • Lee GW; Division of Haematology-Oncology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
Histopathology ; 67(4): 509-19, 2015 Oct.
Article en En | MEDLINE | ID: mdl-25704653
AIMS: The aim of this study was to investigate the expression of Hsp90ß and GRP94, and elucidate the clinical significance of their expression, in patients with resectable non-small-cell lung cancer (NSCLC). METHODS AND RESULTS: Surgical tissue specimens were obtained from 208 patients with NSCLC who underwent surgical resection. The expression levels of Hsp90ß and GRP94 were assessed with tissue microarrays and immunohistochemistry. No correlations were observed between Hsp90ß or GRP94 expression and several clinicopathological factors. The high-Hsp90ß group [median overall survival (OS) 20.4 months; 95% confidence interval (CI) 0.000-40.864] showed a significant decrease in OS as compared with the low-Hsp90ß group (median OS not reached; P = 0.003). In contrast to the Hsp90ß analysis, the GRP94 analysis did not show a difference in OS. Moreover, in subgroup analyses of patients with squamous cell carcinoma histology, OS (P = 0.012) and relapse-free survival (P = 0.044) were significantly worse in the high-Hsp90ß group than in the low-Hsp90ß group. Multivariate analysis suggested that old age [hazard ratio (HR) 1.568; 95% CI 1.019-2.412; P = 0.041], advanced disease (HR 2.066; 95% CI 1.218-3.502; P = 0.007) and high Hsp90ß expression (HR 1.802; 95% CI 1.061-3.060; P = 0.029) were independent poor prognostic factors for OS. CONCLUSIONS: Hsp90ß expression might be a useful marker of poor OS, although further large prospective studies are warranted to validate our findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma de Pulmón de Células no Pequeñas / Proteínas HSP90 de Choque Térmico / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Histopathology Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma de Pulmón de Células no Pequeñas / Proteínas HSP90 de Choque Térmico / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Histopathology Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido