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SWI or T2*: which MRI sequence to use in the detection of cerebral microbleeds? The Karolinska Imaging Dementia Study.
Shams, S; Martola, J; Cavallin, L; Granberg, T; Shams, M; Aspelin, P; Wahlund, L O; Kristoffersen-Wiberg, M.
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  • Shams S; From the Department of Clinical Science, Intervention, and Technology, Division of Medical Imaging and Technology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.) Department of Radiology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.) sara.shams@ki.se.
  • Martola J; From the Department of Clinical Science, Intervention, and Technology, Division of Medical Imaging and Technology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.) Department of Radiology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.).
  • Cavallin L; From the Department of Clinical Science, Intervention, and Technology, Division of Medical Imaging and Technology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.) Department of Radiology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.).
  • Granberg T; From the Department of Clinical Science, Intervention, and Technology, Division of Medical Imaging and Technology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.) Department of Radiology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.).
  • Shams M; From the Department of Clinical Science, Intervention, and Technology, Division of Medical Imaging and Technology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.) Department of Radiology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.).
  • Aspelin P; From the Department of Clinical Science, Intervention, and Technology, Division of Medical Imaging and Technology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.) Department of Radiology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.).
  • Wahlund LO; Department of Neurobiology, Care Sciences, and Society (L.O.W.), Karolinska Institutet, Stockholm, Sweden Division of Clinical Geriatrics (L.O.W.), Karolinska University Hospital, Stockholm, Sweden.
  • Kristoffersen-Wiberg M; From the Department of Clinical Science, Intervention, and Technology, Division of Medical Imaging and Technology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.) Department of Radiology (S.S., J.M., L.C., T.G., M.S., P.A., M.K.-W.).
AJNR Am J Neuroradiol ; 36(6): 1089-95, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25698623
BACKGROUND AND PURPOSE: Cerebral microbleeds are thought to have potentially important clinical implications in dementia and stroke. However, the use of both T2* and SWI MR imaging sequences for microbleed detection has complicated the cross-comparison of study results. We aimed to determine the impact of microbleed sequences on microbleed detection and associated clinical parameters. MATERIALS AND METHODS: Patients from our memory clinic (n = 246; 53% female; mean age, 62) prospectively underwent 3T MR imaging, with conventional thick-section T2*, thick-section SWI, and conventional thin-section SWI. Microbleeds were assessed separately on thick-section SWI, thin-section SWI, and T2* by 3 raters, with varying neuroradiologic experience. Clinical and radiologic parameters from the dementia investigation were analyzed in association with the number of microbleeds in negative binomial regression analyses. RESULTS: Prevalence and number of microbleeds were higher on thick-/thin-section SWI (20/21%) compared with T2*(17%). There was no difference in microbleed prevalence/number between thick- and thin-section SWI. Interrater agreement was excellent for all raters and sequences. Univariate comparisons of clinical parameters between patients with and without microbleeds yielded no difference across sequences. In the regression analysis, only minor differences in clinical associations with the number of microbleeds were noted across sequences. CONCLUSIONS: Due to the increased detection of microbleeds, we recommend SWI as the sequence of choice in microbleed detection. Microbleeds and their association with clinical parameters are robust to the effects of varying MR imaging sequences, suggesting that comparison of results across studies is possible, despite differing microbleed sequences.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Interpretación de Imagen Asistida por Computador / Aumento de la Imagen / Demencia Vascular / Hemorragia Cerebral Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: AJNR Am J Neuroradiol Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Interpretación de Imagen Asistida por Computador / Aumento de la Imagen / Demencia Vascular / Hemorragia Cerebral Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: AJNR Am J Neuroradiol Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos