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Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study.
Tusková, Radka; Lipták, Boris; Szomolányi, Pavol; Vancová, Olga; Ulicná, Olga; Sumbalová, Zuzana; Kucharská, Jarmila; Dubovický, Michal; Trattnig, Siegfried; Liptaj, Tibor; Kasparová, Svatava.
Afiliación
  • Tusková R; Slovak University of Technology in Bratislava, Faculty of Chemical and Food Technology, Institute of Analytical Chemistry, Bratislava, Slovak Republic.
  • Lipták B; Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Bratislava, Slovak Republic.
  • Szomolányi P; High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria.
  • Vancová O; Comenius University in Bratislava, Medical Faculty, Pharmacobiochemical Laboratory of 3rd Department of Internal Medicine, Bratislava, Slovak Republic.
  • Ulicná O; Comenius University in Bratislava, Medical Faculty, Pharmacobiochemical Laboratory of 3rd Department of Internal Medicine, Bratislava, Slovak Republic.
  • Sumbalová Z; Comenius University in Bratislava, Medical Faculty, Pharmacobiochemical Laboratory of 3rd Department of Internal Medicine, Bratislava, Slovak Republic.
  • Kucharská J; Comenius University in Bratislava, Medical Faculty, Pharmacobiochemical Laboratory of 3rd Department of Internal Medicine, Bratislava, Slovak Republic.
  • Dubovický M; Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Bratislava, Slovak Republic.
  • Trattnig S; High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria.
  • Liptaj T; Slovak University of Technology in Bratislava, Faculty of Chemical and Food Technology, Institute of Analytical Chemistry, Bratislava, Slovak Republic.
  • Kasparová S; Slovak University of Technology in Bratislava, Faculty of Chemical and Food Technology, Institute of Analytical Chemistry, Bratislava, Slovak Republic. Electronic address: svatava.kasparova@gmail.com.
Behav Brain Res ; 284: 257-64, 2015 May 01.
Article en En | MEDLINE | ID: mdl-25698600
The aim of study was to search for new biomarkers with a magnetic resonance technique to identify the early stages of dementia, induced by D-galactose, and evaluate Simvastatin therapy. Localized proton magnetic resonance spectroscopy measurements showed a significant decrease in the concentration of N-acetylaspartate+N-acetylaspartylglutamate and myo-inositol in the D-galactose group compared to the control group, and, conversely, an increase of N-acetylaspartate+N-acetylaspartylglutamate in the D-galactose/Simvastatin group. Using a saturation transfer experiment, with phosphorus magnetic resonance spectroscopy, we observed a significant elevation of the forward rate constant of the creatine kinase reaction in the brains of the D-galactose group compared to controls, and subsequently, a significant reduction of this reaction in the D-galactose/Simvastatin group. Spatial learning and memory were evaluated using the modified Morris water maze test. The dynamics of the learning process represented by the learning index revealed a significant reduction in learning in the D-galactose group, but the deficits as a consequence of the D-galactose effects were recovered in the D-galactose/Simvastatin group, in which the learning dynamics resembled those of the control group. By determining the thiobarbituric acid reactive substances and total coenzyme Q9 in plasma, we have shown that long-term administration of D-galactose created conditions for oxidative stress, and that the administration of Simvastatin decreased oxidative stress in plasma. Volumetry analyses from the hippocampal area show a reduction in the segmented area in the D-galactose group, compared with the control group, and an enlarged area in the hippocampus in the d-galactose/Simvastatin group.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Nootrópicos / Simvastatina / Demencia Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Nootrópicos / Simvastatina / Demencia Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos