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Impact of skin capsular distance on the performance of controlled attenuation parameter in patients with chronic liver disease.
Shen, Feng; Zheng, Rui-Dan; Shi, Jun-Ping; Mi, Yu-Qiang; Chen, Guo-Feng; Hu, Xiqi; Liu, Yong-Gang; Wang, Xiao-Ying; Pan, Qin; Chen, Guang-Yu; Chen, Jian-Neng; Xu, Liang; Zhang, Rui-Nan; Xu, Lei-Ming; Fan, Jian-Gao.
Afiliación
  • Shen F; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Zheng RD; Research and Therapy Centre for Liver Disease, Zhengxing Hospital, Zhangzhou, China.
  • Shi JP; Department of Liver Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
  • Mi YQ; Research Institute of Liver Diseases, Tianjin Second People's Hospital, Tianjin, China.
  • Chen GF; Centre for Liver Fibrosis Treatment Unit, 302 Military Hospital, Beijing, China.
  • Hu X; Department of Pathology, Shanghai Medical College of Fudan University, Shanghai, China.
  • Liu YG; Research Institute of Liver Diseases, Tianjin Second People's Hospital, Tianjin, China.
  • Wang XY; Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Pan Q; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Chen GY; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Chen JN; Research and Therapy Centre for Liver Disease, Zhengxing Hospital, Zhangzhou, China.
  • Xu L; Research Institute of Liver Diseases, Tianjin Second People's Hospital, Tianjin, China.
  • Zhang RN; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Xu LM; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Fan JG; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Liver Int ; 35(11): 2392-400, 2015 Nov.
Article en En | MEDLINE | ID: mdl-25689614
BACKGROUND & AIMS: Controlled attenuation parameter (CAP) is a non-invasive method for evaluating hepatic steatosis. However, larger skin capsular distance (SCD) can affect the accuracy. The aim of this study was to investigate the impact of SCD on the diagnostic performance of CAP and liver stiffness measurement (LSM). METHODS: Of 101 patients with non-alcoholic fatty liver disease (NAFLD) and 280 patients with chronic hepatitis B (CHB) who underwent liver biopsy were prospectively recruited. CAP, LSM and SCD were performed using FibroScan with M probe. The areas under receiver operating characteristics curves (AUROCs) were calculated to determine the diagnostic efficacy. The optimal thresholds were defined by the maximum Youden index. RESULTS: SCD (B 30.34, P < 0.001) and hepatic steatosis (B 23.04, P < 0.001) were independently associated with CAP by multivariate analysis. The AUROCs were slightly higher for SCD <25 mm compared to those for SCD ≥25 mm for steatosis ≥5% (0.88 vs. 0.81), >33% (0.90 vs. 0.85) and >66% (0.84 vs. 0.72). For SCD <25 mm, the optimal CAP cut-offs for differentiating steatosis ≥5%, >33% and >66% were 255.0 dB/m, 283.5 dB/m and 293.5 dB/m. However, cut-offs were elevated by approximately 60-70 dB/m for SCD ≥25 mm. When stratified by fibrosis grade, LSM was significantly affected by SCD ≥25 mm for advanced fibrosis (≥F3) in NAFLD, but not in CHB. CONCLUSION: CAP is a promising tool for detecting and quantifying hepatic steatosis. SCD ≥25 mm may cause overestimation of steatosis. Similarly, SCD ≥25 mm affects the detection of advanced fibrosis by LSM in NAFLD patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Hepatitis B Crónica / Diagnóstico por Imagen de Elasticidad / Enfermedad del Hígado Graso no Alcohólico / Hígado Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Liver Int Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Hepatitis B Crónica / Diagnóstico por Imagen de Elasticidad / Enfermedad del Hígado Graso no Alcohólico / Hígado Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Liver Int Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos